The consumption of soy proteins has been reported to have beneficial effects on serum lipids in hypercholesterolemic subjects. It is not known however, whether the lipid lowering effects of soy will vary depending on the hormonal status of women. To test this question, hypercholesterolemic (TC>200mg/dl) women were divided into three groups based on menopausal status: pre-menopausal (pre-M), post-menopausal (post-M), and post-menopausal on hormone replacement therapy (post-M/HRT). Subjects were randomized to a low fat diet (LF) (<25% of Kcals as fat, <200 mg cholesterol/d) or to a similar low fat diet that included 25-50 g of soy protein/d (LF-soy). Fasting blood samples were collected at the beginning and end of the 6 week period. LF: Pre-M Post-M Post-M/HRT LF-Soy; Pre-M Post-M Post-/HRT TC ↔ ↓3.4 ↓1.2 ↓2.1 ↓7.4 ↓6.7 LDL ↓2.0 ↓5.5 ↓3.3 ↓2.6 ↓9.3 ↓2.5 Apo-B ↑2.4 ↓2.7 ↓6.1 ↑2.7 ↓7.5 ↑3.3 The lipid profile changes were generally greatest in the LF-Soy diet groups, particularly post-menopausal women. These results indicate that soy proteins are effective in lowering cholesterol in women.
|Original language||English (US)|
|State||Published - Mar 20 1998|
ASJC Scopus subject areas
- Agricultural and Biological Sciences (miscellaneous)
- Biochemistry, Genetics and Molecular Biology(all)
- Cell Biology