Sox10+ Cells Contribute to Vascular Development in Multiple Organs - Brief Report

Dong Wang, Fan Wu, Haoyong Yuan, Aijun Wang, Gyeong Jin Kang, Tan Truong, Lu Chen, Andrew S. McCallion, Xiaohua Gong, Song Li

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Objective - Previous genetic lineage tracing studies showed that Sox10+ cells differentiate into vascular mural cells, limited to neural crest-derived blood vessels in craniofacial tissues, aortic arch, pulmonary arch arteries, brachiocephalic, carotid arteries, and thymus. The purpose of this study was to investigate the contribution of Sox10+ cells to the vascular development in other tissues and organs and their relationship with neural crest. Approach and Results - Using genetic lineage tracing technique based on Cre/LoxP system, we examined blood vessels in the adult organs of the mice expressing Sox10-Cre/Rosa-LoxP-red fluorescent protein or Wnt1-Cre/Rosa-LoxP-red fluorescent protein by immunohistological analysis. In addition to previously reported tissues and organs derived from neural crest, we showed that Sox10+ cells also contributed to vascular mural cells in the lung, spleen, and kidney, which are derived from non-neural crest origin as evidenced by red fluorescent protein-negative blood vessels in these 3 organs of Wnt1-Cre/Rosa-LoxP-red fluorescent protein mice. Conclusions - This study demonstrates that Sox10+ cells contribute to pericytes and smooth muscle cells in most parts of the body, including those from neural crest and non-neural crest, which has significant implications in vascular remodeling under physiological and pathological conditions.

Original languageEnglish (US)
Pages (from-to)1727-1731
Number of pages5
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Volume37
Issue number9
DOIs
StatePublished - Sep 1 2017

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Blood Vessels
Neural Crest
Pericytes
Thoracic Aorta
Human Body
Carotid Arteries
Thymus Gland
Pulmonary Artery
Smooth Muscle Myocytes
Spleen
Kidney
Lung
red fluorescent protein

Keywords

  • blood vessel
  • mouse
  • pericyte
  • smooth muscle cell
  • vascular remodeling

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Sox10+ Cells Contribute to Vascular Development in Multiple Organs - Brief Report. / Wang, Dong; Wu, Fan; Yuan, Haoyong; Wang, Aijun; Kang, Gyeong Jin; Truong, Tan; Chen, Lu; McCallion, Andrew S.; Gong, Xiaohua; Li, Song.

In: Arteriosclerosis, Thrombosis, and Vascular Biology, Vol. 37, No. 9, 01.09.2017, p. 1727-1731.

Research output: Contribution to journalArticle

Wang, D, Wu, F, Yuan, H, Wang, A, Kang, GJ, Truong, T, Chen, L, McCallion, AS, Gong, X & Li, S 2017, 'Sox10+ Cells Contribute to Vascular Development in Multiple Organs - Brief Report', Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 37, no. 9, pp. 1727-1731. https://doi.org/10.1161/ATVBAHA.117.309774
Wang, Dong ; Wu, Fan ; Yuan, Haoyong ; Wang, Aijun ; Kang, Gyeong Jin ; Truong, Tan ; Chen, Lu ; McCallion, Andrew S. ; Gong, Xiaohua ; Li, Song. / Sox10+ Cells Contribute to Vascular Development in Multiple Organs - Brief Report. In: Arteriosclerosis, Thrombosis, and Vascular Biology. 2017 ; Vol. 37, No. 9. pp. 1727-1731.
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