Source of the fluid component of secretions from tracheal submucosal glands in cats

R. J. Corrales, J. A. Nadel, Jonathan Widdicombe

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The idea that the fluid component of cat treacheal submucosal glands secretion is produced by Na-linked secretion of Cl was tested. Gland secretion was stimulated with phenylephrine; gland fluid flow, net salt movement, and output of 35SO4-labeled macromolecules were measured. With Cl, I, NO3, or Br as the major anion, phenylephrine caused equal increases in gland flow and output of 35S-labeled macromolecules while increasing net transepithelial 22Na movement from 0 to about 10 μeq · cm-2 · h-1. With the impermeant gluconate as a major anion, phenylephrine caused the same increase in output of 35S label, a smaller increase in gland flow, and had no effect on net 22Na movement. Short circuiting in the presence of Cl, or high concentrations of the loop diuretics, furosemide or bumetanide, did not alter the actions of phenylephrine. Ouabain or replacement of Na by choline or Li abolished all secretory effects of phenylephrine. We conclude that active Cl secretion is not responsible for the transepithelial flows of salt and water induced by phenylephrine. Instead, these flows may be secondary to the release of osmotically active components of the secretory granules.

Original languageEnglish (US)
Pages (from-to)1076-1082
Number of pages7
JournalJournal of Applied Physiology Respiratory Environmental and Exercise Physiology
Volume56
Issue number4
StatePublished - 1984
Externally publishedYes

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Fluids and Secretions
Phenylephrine
Cats
Anions
Salts
Sodium Potassium Chloride Symporter Inhibitors
Bumetanide
Furosemide
Secretory Vesicles
Ouabain
Choline
Water

ASJC Scopus subject areas

  • Endocrinology
  • Physiology

Cite this

Source of the fluid component of secretions from tracheal submucosal glands in cats. / Corrales, R. J.; Nadel, J. A.; Widdicombe, Jonathan.

In: Journal of Applied Physiology Respiratory Environmental and Exercise Physiology, Vol. 56, No. 4, 1984, p. 1076-1082.

Research output: Contribution to journalArticle

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