Abstract
Cetacean health may be potentially affected by anthropogenic sound. We have initiated investigations on the effect of low-frequency underwater sound on immunological gene transcript profiles of captive bottlenose dolphins (Tursiops truncatus) using a probe-based quantitative gene expression assay. Six immunologic genes (IL-2Rα, -4, -10, -12, TNFα and IFNγ) were selected for analysis using two validated housekeeping genes (PGK1 and HPRT1) as reference genes. Twenty-four blood samples from six clinically healthy individuals and six blood samples from individuals after sound exposures were available. The gene transcript profile of sound-exposed dolphins was consistent with a stress-induced TH 2 shift profile as compared to controls. This study may lead to better understanding of the effects of anthropogenic sound on immune responses of cetaceans.
Original language | English (US) |
---|---|
Pages (from-to) | 601-605 |
Number of pages | 5 |
Journal | Journal of Veterinary Medical Science |
Volume | 80 |
Issue number | 4 |
DOIs |
|
State | Published - Apr 1 2018 |
Keywords
- Cytokine
- Dolphin
- Immune response
- QRT-PCR
- Sound
ASJC Scopus subject areas
- veterinary(all)