Sorbitol induced breath hydrogen in healthy volunteers

Nirmal S Mann, Eddie C. Cheung

Research output: Contribution to journalArticle

Abstract

Background: We have previously shown that healthy male volunteers after oral lactulose develop significant abdominal bloating, excessive flatus passage and increased breath hydrogen. Objective: The aim of this study was to measure breath hydrogen, abdominal bloating and flatus passage after oral sorbitol and to compare these parameters with those produced by lactulose. Materials and Methods: The same normal volunteers who had participated in the lactulose study also were used in this study. After oral sorbitol, bloating score, number of flatus passage and breath hydrogen over a period of 8 hours was measured. These parameters were compared with those which had been obtained after lactulose. Results: These male healthy volunteers after oral sorbitol produced breath hydrogen, had abdominal bloating and passed flatus similar to that produced after lactulose. Conclusion: Gastrointestinal symptoms produced by some foods and fruits in otherwise healthy persons may be due to the sorbitol content of those foods. The manufacturers should clearly state the amount of sorbitol in such foods.

Original languageEnglish (US)
Pages (from-to)31-33
Number of pages3
JournalInternational Medical Journal
Volume14
Issue number1
StatePublished - Mar 2007

Fingerprint

Lactulose
Sorbitol
Flatulence
Hydrogen
Healthy Volunteers
Food
Fruit

Keywords

  • Bloating
  • Breath hydrogen
  • Flatus
  • Lactulose
  • Sorbitol

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Sorbitol induced breath hydrogen in healthy volunteers. / Mann, Nirmal S; Cheung, Eddie C.

In: International Medical Journal, Vol. 14, No. 1, 03.2007, p. 31-33.

Research output: Contribution to journalArticle

@article{7409a2f5941a4ed7b74668998a005e8d,
title = "Sorbitol induced breath hydrogen in healthy volunteers",
abstract = "Background: We have previously shown that healthy male volunteers after oral lactulose develop significant abdominal bloating, excessive flatus passage and increased breath hydrogen. Objective: The aim of this study was to measure breath hydrogen, abdominal bloating and flatus passage after oral sorbitol and to compare these parameters with those produced by lactulose. Materials and Methods: The same normal volunteers who had participated in the lactulose study also were used in this study. After oral sorbitol, bloating score, number of flatus passage and breath hydrogen over a period of 8 hours was measured. These parameters were compared with those which had been obtained after lactulose. Results: These male healthy volunteers after oral sorbitol produced breath hydrogen, had abdominal bloating and passed flatus similar to that produced after lactulose. Conclusion: Gastrointestinal symptoms produced by some foods and fruits in otherwise healthy persons may be due to the sorbitol content of those foods. The manufacturers should clearly state the amount of sorbitol in such foods.",
keywords = "Bloating, Breath hydrogen, Flatus, Lactulose, Sorbitol",
author = "Mann, {Nirmal S} and Cheung, {Eddie C.}",
year = "2007",
month = "3",
language = "English (US)",
volume = "14",
pages = "31--33",
journal = "International Medical Journal",
issn = "1341-2051",
publisher = "Japan International Cultural Exchange Foundation",
number = "1",

}

TY - JOUR

T1 - Sorbitol induced breath hydrogen in healthy volunteers

AU - Mann, Nirmal S

AU - Cheung, Eddie C.

PY - 2007/3

Y1 - 2007/3

N2 - Background: We have previously shown that healthy male volunteers after oral lactulose develop significant abdominal bloating, excessive flatus passage and increased breath hydrogen. Objective: The aim of this study was to measure breath hydrogen, abdominal bloating and flatus passage after oral sorbitol and to compare these parameters with those produced by lactulose. Materials and Methods: The same normal volunteers who had participated in the lactulose study also were used in this study. After oral sorbitol, bloating score, number of flatus passage and breath hydrogen over a period of 8 hours was measured. These parameters were compared with those which had been obtained after lactulose. Results: These male healthy volunteers after oral sorbitol produced breath hydrogen, had abdominal bloating and passed flatus similar to that produced after lactulose. Conclusion: Gastrointestinal symptoms produced by some foods and fruits in otherwise healthy persons may be due to the sorbitol content of those foods. The manufacturers should clearly state the amount of sorbitol in such foods.

AB - Background: We have previously shown that healthy male volunteers after oral lactulose develop significant abdominal bloating, excessive flatus passage and increased breath hydrogen. Objective: The aim of this study was to measure breath hydrogen, abdominal bloating and flatus passage after oral sorbitol and to compare these parameters with those produced by lactulose. Materials and Methods: The same normal volunteers who had participated in the lactulose study also were used in this study. After oral sorbitol, bloating score, number of flatus passage and breath hydrogen over a period of 8 hours was measured. These parameters were compared with those which had been obtained after lactulose. Results: These male healthy volunteers after oral sorbitol produced breath hydrogen, had abdominal bloating and passed flatus similar to that produced after lactulose. Conclusion: Gastrointestinal symptoms produced by some foods and fruits in otherwise healthy persons may be due to the sorbitol content of those foods. The manufacturers should clearly state the amount of sorbitol in such foods.

KW - Bloating

KW - Breath hydrogen

KW - Flatus

KW - Lactulose

KW - Sorbitol

UR - http://www.scopus.com/inward/record.url?scp=34047249625&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34047249625&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:34047249625

VL - 14

SP - 31

EP - 33

JO - International Medical Journal

JF - International Medical Journal

SN - 1341-2051

IS - 1

ER -