Abstract
Sorbitol levels in heart were determined in streptozotocin-induced diabetic rats. Significantly higher levels were found in hearts of diabetic rats compared to normal rats. The findings are compatible with either significantly higher de novo synthesis of sorbitol in heart than is generally believed or uptake of circulating sorbitol by heart as previously indicated by nuclear magnetic resonance (NMR) in vivo metabolic imaging. Sorbitol accumulation in heart tissue may play a role in the pathogenesis of diabetic cardiomyopathy as has been implicated in cataract formation.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2491-2493 |
| Number of pages | 3 |
| Journal | Life Sciences |
| Volume | 45 |
| Issue number | 25 |
| DOIs | |
| State | Published - 1989 |
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ASJC Scopus subject areas
- Pharmacology
Cite this
Sorbitol accumulation in heart : Implication for diabetic cardiomyopathy. / Nakada, Tsutomu; Kwee, Ingrid.
In: Life Sciences, Vol. 45, No. 25, 1989, p. 2491-2493.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Sorbitol accumulation in heart
T2 - Implication for diabetic cardiomyopathy
AU - Nakada, Tsutomu
AU - Kwee, Ingrid
PY - 1989
Y1 - 1989
N2 - Sorbitol levels in heart were determined in streptozotocin-induced diabetic rats. Significantly higher levels were found in hearts of diabetic rats compared to normal rats. The findings are compatible with either significantly higher de novo synthesis of sorbitol in heart than is generally believed or uptake of circulating sorbitol by heart as previously indicated by nuclear magnetic resonance (NMR) in vivo metabolic imaging. Sorbitol accumulation in heart tissue may play a role in the pathogenesis of diabetic cardiomyopathy as has been implicated in cataract formation.
AB - Sorbitol levels in heart were determined in streptozotocin-induced diabetic rats. Significantly higher levels were found in hearts of diabetic rats compared to normal rats. The findings are compatible with either significantly higher de novo synthesis of sorbitol in heart than is generally believed or uptake of circulating sorbitol by heart as previously indicated by nuclear magnetic resonance (NMR) in vivo metabolic imaging. Sorbitol accumulation in heart tissue may play a role in the pathogenesis of diabetic cardiomyopathy as has been implicated in cataract formation.
UR - http://www.scopus.com/inward/record.url?scp=0024848282&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0024848282&partnerID=8YFLogxK
U2 - 10.1016/0024-3205(89)90016-7
DO - 10.1016/0024-3205(89)90016-7
M3 - Article
C2 - 2607890
AN - SCOPUS:0024848282
VL - 45
SP - 2491
EP - 2493
JO - Life Sciences
JF - Life Sciences
SN - 0024-3205
IS - 25
ER -