Sorbitol accumulation in heart: Implication for diabetic cardiomyopathy

Tsutomu Nakada; Ingrid Kwee

doi:10.1016/0024-3205(89)90016-7

Sorbitol accumulation in heart: Implication for diabetic cardiomyopathy

Tsutomu Nakada, Ingrid Kwee

Neurology

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Sorbitol levels in heart were determined in streptozotocin-induced diabetic rats. Significantly higher levels were found in hearts of diabetic rats compared to normal rats. The findings are compatible with either significantly higher de novo synthesis of sorbitol in heart than is generally believed or uptake of circulating sorbitol by heart as previously indicated by nuclear magnetic resonance (NMR) in vivo metabolic imaging. Sorbitol accumulation in heart tissue may play a role in the pathogenesis of diabetic cardiomyopathy as has been implicated in cataract formation.

Original language	English (US)
Pages (from-to)	2491-2493
Number of pages	3
Journal	Life Sciences
Volume	45
Issue number	25
DOIs	https://doi.org/10.1016/0024-3205(89)90016-7
State	Published - 1989

ASJC Scopus subject areas

Pharmacology

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title = "Sorbitol accumulation in heart: Implication for diabetic cardiomyopathy",

abstract = "Sorbitol levels in heart were determined in streptozotocin-induced diabetic rats. Significantly higher levels were found in hearts of diabetic rats compared to normal rats. The findings are compatible with either significantly higher de novo synthesis of sorbitol in heart than is generally believed or uptake of circulating sorbitol by heart as previously indicated by nuclear magnetic resonance (NMR) in vivo metabolic imaging. Sorbitol accumulation in heart tissue may play a role in the pathogenesis of diabetic cardiomyopathy as has been implicated in cataract formation.",

author = "Tsutomu Nakada and Ingrid Kwee",

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AU - Nakada, Tsutomu

AU - Kwee, Ingrid

PY - 1989

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AB - Sorbitol levels in heart were determined in streptozotocin-induced diabetic rats. Significantly higher levels were found in hearts of diabetic rats compared to normal rats. The findings are compatible with either significantly higher de novo synthesis of sorbitol in heart than is generally believed or uptake of circulating sorbitol by heart as previously indicated by nuclear magnetic resonance (NMR) in vivo metabolic imaging. Sorbitol accumulation in heart tissue may play a role in the pathogenesis of diabetic cardiomyopathy as has been implicated in cataract formation.

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Sorbitol accumulation in heart: Implication for diabetic cardiomyopathy

Abstract

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