Sorbitol accumulation in heart: Implication for diabetic cardiomyopathy

Tsutomu Nakada; Ingrid Kwee

doi:10.1016/0024-3205(89)90016-7

Sorbitol accumulation in heart: Implication for diabetic cardiomyopathy

Tsutomu Nakada, Ingrid Kwee

Neurology

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Sorbitol levels in heart were determined in streptozotocin-induced diabetic rats. Significantly higher levels were found in hearts of diabetic rats compared to normal rats. The findings are compatible with either significantly higher de novo synthesis of sorbitol in heart than is generally believed or uptake of circulating sorbitol by heart as previously indicated by nuclear magnetic resonance (NMR) in vivo metabolic imaging. Sorbitol accumulation in heart tissue may play a role in the pathogenesis of diabetic cardiomyopathy as has been implicated in cataract formation.

Original language	English (US)
Pages (from-to)	2491-2493
Number of pages	3
Journal	Life Sciences
Volume	45
Issue number	25
DOIs	https://doi.org/10.1016/0024-3205(89)90016-7
State	Published - 1989

ASJC Scopus subject areas

Pharmacology

Access to Document

10.1016/0024-3205(89)90016-7

Cite this

@article{e3853113b35c46f1be8b4b44c10aef94,

title = "Sorbitol accumulation in heart: Implication for diabetic cardiomyopathy",

abstract = "Sorbitol levels in heart were determined in streptozotocin-induced diabetic rats. Significantly higher levels were found in hearts of diabetic rats compared to normal rats. The findings are compatible with either significantly higher de novo synthesis of sorbitol in heart than is generally believed or uptake of circulating sorbitol by heart as previously indicated by nuclear magnetic resonance (NMR) in vivo metabolic imaging. Sorbitol accumulation in heart tissue may play a role in the pathogenesis of diabetic cardiomyopathy as has been implicated in cataract formation.",

author = "Tsutomu Nakada and Ingrid Kwee",

year = "1989",

doi = "10.1016/0024-3205(89)90016-7",

language = "English (US)",

volume = "45",

pages = "2491--2493",

journal = "Life Sciences",

issn = "0024-3205",

publisher = "Elsevier Inc.",

number = "25",

}

TY - JOUR

T1 - Sorbitol accumulation in heart

T2 - Implication for diabetic cardiomyopathy

AU - Nakada, Tsutomu

AU - Kwee, Ingrid

PY - 1989

Y1 - 1989

N2 - Sorbitol levels in heart were determined in streptozotocin-induced diabetic rats. Significantly higher levels were found in hearts of diabetic rats compared to normal rats. The findings are compatible with either significantly higher de novo synthesis of sorbitol in heart than is generally believed or uptake of circulating sorbitol by heart as previously indicated by nuclear magnetic resonance (NMR) in vivo metabolic imaging. Sorbitol accumulation in heart tissue may play a role in the pathogenesis of diabetic cardiomyopathy as has been implicated in cataract formation.

AB - Sorbitol levels in heart were determined in streptozotocin-induced diabetic rats. Significantly higher levels were found in hearts of diabetic rats compared to normal rats. The findings are compatible with either significantly higher de novo synthesis of sorbitol in heart than is generally believed or uptake of circulating sorbitol by heart as previously indicated by nuclear magnetic resonance (NMR) in vivo metabolic imaging. Sorbitol accumulation in heart tissue may play a role in the pathogenesis of diabetic cardiomyopathy as has been implicated in cataract formation.

UR - http://www.scopus.com/inward/record.url?scp=0024848282&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024848282&partnerID=8YFLogxK

U2 - 10.1016/0024-3205(89)90016-7

DO - 10.1016/0024-3205(89)90016-7

M3 - Article

C2 - 2607890

AN - SCOPUS:0024848282

VL - 45

SP - 2491

EP - 2493

JO - Life Sciences

JF - Life Sciences

SN - 0024-3205

IS - 25

ER -

Sorbitol accumulation in heart: Implication for diabetic cardiomyopathy

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this