Sometimes a great motion: The application of transient electric birefringence to the study of macromolecular structure

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Abstract

First described in the late 1800s, the phenomenon of electric birefringence is becoming increasingly useful as a probe of the solution conformations of proteins and nucleic acids. The birefringence response to a transient electric field is a sensitive indicator of the rotational motions (and hence the physical dimensions) of macromolecules in solution. Recent advances, both in instrumentation and in the efficient production of high-quality biopolymers, have dramatically increased the sensitivity and range of applicability of the method.

Original languageEnglish (US)
Pages (from-to)643-649
Number of pages7
JournalCurrent Opinion in Structural Biology
Volume6
Issue number5
DOIs
StatePublished - Oct 1996
Externally publishedYes

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Birefringence
Nucleic Acid Conformation
Biopolymers

ASJC Scopus subject areas

  • Molecular Biology
  • Structural Biology

Cite this

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