Somatostatin Regulates aggressive behavior in an african cichlid fish

Brian C. Trainor, Hans A. Hofmann

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Animals respond to environmental and social change with plasticity in the neural substrates underlying particular behavioral states. In the African cichlid fish Astatotilapia burtoni, social dominance status in males is accompanied by reduced somatic growth rate as well as increased somatostatin neuron size in the preoptic area. Although somatostatin is commonly studied within the context of growth, we show here for the first time that this ancient neuropeptide also plays a role in controlling social behavior. Somatostatin antagonists increased aggressive behavior in a dose-dependent fashion and the potent somatostatin agonist octreotide decreased aggression. We cloned and sequenced the genes encoding two somatostatin receptor subtypes in this species to study transcription in the gonads. When we examined somatostatin receptor gene expression in testes, expression of the somatostatin type 3 receptor was negatively correlated with an aggressive display and androgen levels. However, octreotide treatment did not reduce plasma testosterone or 11-ketotestosterone levels, suggesting that the behavioral effects of somatostatin are not mediated by androgens. These results show that somatostatin has important effects on social behavior. In dominant male A. burtoni, somatostatin may function to contain energetically costly processes such as somatic growth and aggressive behavior.

Original languageEnglish (US)
Pages (from-to)5119-5125
Number of pages7
JournalEndocrinology
Volume147
Issue number11
DOIs
StatePublished - 2006
Externally publishedYes

Fingerprint

Cichlids
Somatostatin
Somatostatin Receptors
Octreotide
Social Behavior
Androgens
Growth
Social Dominance
Neuronal Plasticity
Preoptic Area
Gonads
Social Change
Neuropeptides
Aggression
Testosterone
Testis
Gene Expression
Neurons
Genes

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Somatostatin Regulates aggressive behavior in an african cichlid fish. / Trainor, Brian C.; Hofmann, Hans A.

In: Endocrinology, Vol. 147, No. 11, 2006, p. 5119-5125.

Research output: Contribution to journalArticle

Trainor, Brian C. ; Hofmann, Hans A. / Somatostatin Regulates aggressive behavior in an african cichlid fish. In: Endocrinology. 2006 ; Vol. 147, No. 11. pp. 5119-5125.
@article{4c9eeb927682413fbc32a0c361ab72bc,
title = "Somatostatin Regulates aggressive behavior in an african cichlid fish",
abstract = "Animals respond to environmental and social change with plasticity in the neural substrates underlying particular behavioral states. In the African cichlid fish Astatotilapia burtoni, social dominance status in males is accompanied by reduced somatic growth rate as well as increased somatostatin neuron size in the preoptic area. Although somatostatin is commonly studied within the context of growth, we show here for the first time that this ancient neuropeptide also plays a role in controlling social behavior. Somatostatin antagonists increased aggressive behavior in a dose-dependent fashion and the potent somatostatin agonist octreotide decreased aggression. We cloned and sequenced the genes encoding two somatostatin receptor subtypes in this species to study transcription in the gonads. When we examined somatostatin receptor gene expression in testes, expression of the somatostatin type 3 receptor was negatively correlated with an aggressive display and androgen levels. However, octreotide treatment did not reduce plasma testosterone or 11-ketotestosterone levels, suggesting that the behavioral effects of somatostatin are not mediated by androgens. These results show that somatostatin has important effects on social behavior. In dominant male A. burtoni, somatostatin may function to contain energetically costly processes such as somatic growth and aggressive behavior.",
author = "Trainor, {Brian C.} and Hofmann, {Hans A.}",
year = "2006",
doi = "10.1210/en.2006-0511",
language = "English (US)",
volume = "147",
pages = "5119--5125",
journal = "Endocrinology",
issn = "0013-7227",
publisher = "The Endocrine Society",
number = "11",

}

TY - JOUR

T1 - Somatostatin Regulates aggressive behavior in an african cichlid fish

AU - Trainor, Brian C.

AU - Hofmann, Hans A.

PY - 2006

Y1 - 2006

N2 - Animals respond to environmental and social change with plasticity in the neural substrates underlying particular behavioral states. In the African cichlid fish Astatotilapia burtoni, social dominance status in males is accompanied by reduced somatic growth rate as well as increased somatostatin neuron size in the preoptic area. Although somatostatin is commonly studied within the context of growth, we show here for the first time that this ancient neuropeptide also plays a role in controlling social behavior. Somatostatin antagonists increased aggressive behavior in a dose-dependent fashion and the potent somatostatin agonist octreotide decreased aggression. We cloned and sequenced the genes encoding two somatostatin receptor subtypes in this species to study transcription in the gonads. When we examined somatostatin receptor gene expression in testes, expression of the somatostatin type 3 receptor was negatively correlated with an aggressive display and androgen levels. However, octreotide treatment did not reduce plasma testosterone or 11-ketotestosterone levels, suggesting that the behavioral effects of somatostatin are not mediated by androgens. These results show that somatostatin has important effects on social behavior. In dominant male A. burtoni, somatostatin may function to contain energetically costly processes such as somatic growth and aggressive behavior.

AB - Animals respond to environmental and social change with plasticity in the neural substrates underlying particular behavioral states. In the African cichlid fish Astatotilapia burtoni, social dominance status in males is accompanied by reduced somatic growth rate as well as increased somatostatin neuron size in the preoptic area. Although somatostatin is commonly studied within the context of growth, we show here for the first time that this ancient neuropeptide also plays a role in controlling social behavior. Somatostatin antagonists increased aggressive behavior in a dose-dependent fashion and the potent somatostatin agonist octreotide decreased aggression. We cloned and sequenced the genes encoding two somatostatin receptor subtypes in this species to study transcription in the gonads. When we examined somatostatin receptor gene expression in testes, expression of the somatostatin type 3 receptor was negatively correlated with an aggressive display and androgen levels. However, octreotide treatment did not reduce plasma testosterone or 11-ketotestosterone levels, suggesting that the behavioral effects of somatostatin are not mediated by androgens. These results show that somatostatin has important effects on social behavior. In dominant male A. burtoni, somatostatin may function to contain energetically costly processes such as somatic growth and aggressive behavior.

UR - http://www.scopus.com/inward/record.url?scp=33751244817&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33751244817&partnerID=8YFLogxK

U2 - 10.1210/en.2006-0511

DO - 10.1210/en.2006-0511

M3 - Article

C2 - 16887916

AN - SCOPUS:33751244817

VL - 147

SP - 5119

EP - 5125

JO - Endocrinology

JF - Endocrinology

SN - 0013-7227

IS - 11

ER -