Somatostatin-immunoreactivity in the hippocampus of mouse, rat, guinea pig, and rabbit

P. S. Buckmaster, D. D. Kunkel, R. J. Robbins, Philip A Schwartzkroin

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

The hippocampi of species commonly used for in vitro physiologic studies were examined to determine if there were species-specific and regional differences in somatostatin immunoreactivity. The distributions of somatostatin-immunoreactive somata and fiber plexuses were determined, and the concentration of somatostatin along the septotemporal axis of the hippocampus was measured using a radioimmunoassay. There are many similarities in the patterns of somatostatin immunoreactivity in the hippocampi of mice, rats, guinea pigs, and rabbits. All species had a relatively even distribution of somatostatin-positive perikarya across three fields of the hippocampus (dentate gyrus, CA3, and CA1-2), a similar distribution of somatostatin-immunoreactive perikarya across the strata of the CA1-2 field and the dentate gyrus, and more somatostatin-positive cells in temporal than in septal hippocampus. However, there are species-specific differences in the distribution of somatostatin-immunoreactive perikarya across the strata of CA3. In addition, unlike the other species examined, mice appeared not to have a somatostatin-immunoreactive fiber plexus in the molecular layer of the dentate gyrus. The functional significance of these differences remains to be determined.

Original languageEnglish (US)
Pages (from-to)167-180
Number of pages14
JournalHippocampus
Volume4
Issue number2
StatePublished - 1994
Externally publishedYes

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Somatostatin
Hippocampus
Guinea Pigs
Rabbits
Dentate Gyrus
Somatostatin-Secreting Cells
Carisoprodol
Radioimmunoassay

Keywords

  • Dentate gyrus
  • Immunocytochemistry
  • Peptide
  • Radioimmunoassay
  • Rodents

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Somatostatin-immunoreactivity in the hippocampus of mouse, rat, guinea pig, and rabbit. / Buckmaster, P. S.; Kunkel, D. D.; Robbins, R. J.; Schwartzkroin, Philip A.

In: Hippocampus, Vol. 4, No. 2, 1994, p. 167-180.

Research output: Contribution to journalArticle

Buckmaster, PS, Kunkel, DD, Robbins, RJ & Schwartzkroin, PA 1994, 'Somatostatin-immunoreactivity in the hippocampus of mouse, rat, guinea pig, and rabbit', Hippocampus, vol. 4, no. 2, pp. 167-180.
Buckmaster, P. S. ; Kunkel, D. D. ; Robbins, R. J. ; Schwartzkroin, Philip A. / Somatostatin-immunoreactivity in the hippocampus of mouse, rat, guinea pig, and rabbit. In: Hippocampus. 1994 ; Vol. 4, No. 2. pp. 167-180.
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