Somatostatin and somatostatin receptor gene expression in dominant and subordinate males of an African cichlid fish

Brian C. Trainor, Hans A. Hofmann

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Somatostatin is a neuropeptide best known for its inhibitory effects on growth hormone secretion and has recently been implicated in the control of social behavior. Several somatostatin receptor subtypes have been identified in vertebrates, but the functional basis for this diversity is still unclear. Here we investigate the expression levels of the somatostatin prepropeptide and two of its receptors, sstR2, and sstR3, in the brains of socially dominant and subordinate Astatotilapia burtoni males using real-time PCR. Dominant males had higher somatostatin prepropeptide and sstR3 expression in hypothalamus compared to subordinate males. Hypothalamic sstR2 expression did not differ. There were no differences in gene expression in the telencephalon. We also observed an interesting difference between dominants and subordinates in the relationship between hypothalamic sstR2 expression and body size. As would be predicted based on the inhibitory effects of somatostatin on somatic growth, sstR2 expression was negatively correlated with body size in dominant males. In contrast sstR2 expression was positively correlated with body size in subordinate males. These results suggest that in A. burtoni social status affects the relationships between somatostatin prepropeptide and receptor gene expression in the hypothalamus and the control of somatic growth.

Original languageEnglish (US)
Pages (from-to)314-320
Number of pages7
JournalBehavioural Brain Research
Volume179
Issue number2
DOIs
StatePublished - May 16 2007
Externally publishedYes

Fingerprint

Cichlids
Somatostatin Receptors
Somatostatin
Gene Expression
Body Size
Hypothalamus
Telencephalon
Social Behavior
Growth
Neuropeptides
Growth Hormone
Vertebrates
Real-Time Polymerase Chain Reaction
Brain

Keywords

  • Aggression
  • Astatotilapia burtoni
  • Growth
  • Pre-optic area
  • Social behavior

ASJC Scopus subject areas

  • Behavioral Neuroscience

Cite this

Somatostatin and somatostatin receptor gene expression in dominant and subordinate males of an African cichlid fish. / Trainor, Brian C.; Hofmann, Hans A.

In: Behavioural Brain Research, Vol. 179, No. 2, 16.05.2007, p. 314-320.

Research output: Contribution to journalArticle

@article{9b739153706047e19670899b4ca787bc,
title = "Somatostatin and somatostatin receptor gene expression in dominant and subordinate males of an African cichlid fish",
abstract = "Somatostatin is a neuropeptide best known for its inhibitory effects on growth hormone secretion and has recently been implicated in the control of social behavior. Several somatostatin receptor subtypes have been identified in vertebrates, but the functional basis for this diversity is still unclear. Here we investigate the expression levels of the somatostatin prepropeptide and two of its receptors, sstR2, and sstR3, in the brains of socially dominant and subordinate Astatotilapia burtoni males using real-time PCR. Dominant males had higher somatostatin prepropeptide and sstR3 expression in hypothalamus compared to subordinate males. Hypothalamic sstR2 expression did not differ. There were no differences in gene expression in the telencephalon. We also observed an interesting difference between dominants and subordinates in the relationship between hypothalamic sstR2 expression and body size. As would be predicted based on the inhibitory effects of somatostatin on somatic growth, sstR2 expression was negatively correlated with body size in dominant males. In contrast sstR2 expression was positively correlated with body size in subordinate males. These results suggest that in A. burtoni social status affects the relationships between somatostatin prepropeptide and receptor gene expression in the hypothalamus and the control of somatic growth.",
keywords = "Aggression, Astatotilapia burtoni, Growth, Pre-optic area, Social behavior",
author = "Trainor, {Brian C.} and Hofmann, {Hans A.}",
year = "2007",
month = "5",
day = "16",
doi = "10.1016/j.bbr.2007.02.014",
language = "English (US)",
volume = "179",
pages = "314--320",
journal = "Behavioural Brain Research",
issn = "0166-4328",
publisher = "Elsevier",
number = "2",

}

TY - JOUR

T1 - Somatostatin and somatostatin receptor gene expression in dominant and subordinate males of an African cichlid fish

AU - Trainor, Brian C.

AU - Hofmann, Hans A.

PY - 2007/5/16

Y1 - 2007/5/16

N2 - Somatostatin is a neuropeptide best known for its inhibitory effects on growth hormone secretion and has recently been implicated in the control of social behavior. Several somatostatin receptor subtypes have been identified in vertebrates, but the functional basis for this diversity is still unclear. Here we investigate the expression levels of the somatostatin prepropeptide and two of its receptors, sstR2, and sstR3, in the brains of socially dominant and subordinate Astatotilapia burtoni males using real-time PCR. Dominant males had higher somatostatin prepropeptide and sstR3 expression in hypothalamus compared to subordinate males. Hypothalamic sstR2 expression did not differ. There were no differences in gene expression in the telencephalon. We also observed an interesting difference between dominants and subordinates in the relationship between hypothalamic sstR2 expression and body size. As would be predicted based on the inhibitory effects of somatostatin on somatic growth, sstR2 expression was negatively correlated with body size in dominant males. In contrast sstR2 expression was positively correlated with body size in subordinate males. These results suggest that in A. burtoni social status affects the relationships between somatostatin prepropeptide and receptor gene expression in the hypothalamus and the control of somatic growth.

AB - Somatostatin is a neuropeptide best known for its inhibitory effects on growth hormone secretion and has recently been implicated in the control of social behavior. Several somatostatin receptor subtypes have been identified in vertebrates, but the functional basis for this diversity is still unclear. Here we investigate the expression levels of the somatostatin prepropeptide and two of its receptors, sstR2, and sstR3, in the brains of socially dominant and subordinate Astatotilapia burtoni males using real-time PCR. Dominant males had higher somatostatin prepropeptide and sstR3 expression in hypothalamus compared to subordinate males. Hypothalamic sstR2 expression did not differ. There were no differences in gene expression in the telencephalon. We also observed an interesting difference between dominants and subordinates in the relationship between hypothalamic sstR2 expression and body size. As would be predicted based on the inhibitory effects of somatostatin on somatic growth, sstR2 expression was negatively correlated with body size in dominant males. In contrast sstR2 expression was positively correlated with body size in subordinate males. These results suggest that in A. burtoni social status affects the relationships between somatostatin prepropeptide and receptor gene expression in the hypothalamus and the control of somatic growth.

KW - Aggression

KW - Astatotilapia burtoni

KW - Growth

KW - Pre-optic area

KW - Social behavior

UR - http://www.scopus.com/inward/record.url?scp=33947652191&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33947652191&partnerID=8YFLogxK

U2 - 10.1016/j.bbr.2007.02.014

DO - 10.1016/j.bbr.2007.02.014

M3 - Article

C2 - 17374406

AN - SCOPUS:33947652191

VL - 179

SP - 314

EP - 320

JO - Behavioural Brain Research

JF - Behavioural Brain Research

SN - 0166-4328

IS - 2

ER -