Somatic inactivation of E-cadherin and p53 in mice leads to metastatic lobular mammary carcinoma through induction of anoikis resistance and angiogenesis

Patrick W B Derksen, Xiaoling Liu, Francis Saridin, Hanneke van der Gulden, John Zevenhoven, Bastiaan Evers, Judy R. van Beijnum, Arjan W. Griffioen, Jacqueline Vink, Paul Krimpenfort, Johannes L. Peterse, Robert Cardiff, Anton Berns, Jos Jonkers

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Abstract

Metastatic disease is the primary cause of death in breast cancer, the most common malignancy in Western women. Loss of E-cadherin is associated with tumor metastasis, as well as with invasive lobular carcinoma (ILC), which accounts for 10%-15% of all breast cancers. To study the role of E-cadherin in breast oncogenesis, we have introduced conditional E-cadherin mutations into a mouse tumor model based on epithelium-specific knockout of p53. Combined loss of E-cadherin and p53 resulted in accelerated development of invasive and metastatic mammary carcinomas, which show strong resemblance to human ILC. Moreover, loss of E-cadherin induced anoikis resistance and facilitated angiogenesis, thus promoting metastatic disease. Our results suggest that loss of E-cadherin contributes to both mammary tumor initiation and metastasis.

Original languageEnglish (US)
Pages (from-to)437-449
Number of pages13
JournalCancer Cell
Volume10
Issue number5
DOIs
StatePublished - Nov 1 2006

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Keywords

  • CELLCYCLE

ASJC Scopus subject areas

  • Cancer Research
  • Cell Biology
  • Oncology

Cite this

Derksen, P. W. B., Liu, X., Saridin, F., van der Gulden, H., Zevenhoven, J., Evers, B., van Beijnum, J. R., Griffioen, A. W., Vink, J., Krimpenfort, P., Peterse, J. L., Cardiff, R., Berns, A., & Jonkers, J. (2006). Somatic inactivation of E-cadherin and p53 in mice leads to metastatic lobular mammary carcinoma through induction of anoikis resistance and angiogenesis. Cancer Cell, 10(5), 437-449. https://doi.org/10.1016/j.ccr.2006.09.013