Abstract
In the premature infant, poor growth in utero (fetal growth restriction) and in the first weeks of life (postnatal growth restriction) are associated with increased risk for bronchopulmonary dysplasia and pulmonary hypertension. In this review, we summarize the epidemiologic data supporting these associations, present a novel rodent model of postnatal growth restriction, and review 5 promising mechanisms by which poor nutrition may affect the developing lung. These observations support the hypothesis that nutritional and (or) pharmacologic interventions early in life may be able to decrease risk of the pulmonary complications of extreme prematurity.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 197-205 |
| Number of pages | 9 |
| Journal | Canadian Journal of Physiology and Pharmacology |
| Volume | 97 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jan 1 2019 |
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Keywords
- Bronchopulmonary dysplasia
- Dyslipidemia
- Fetal growth restriction
- Inflammation
- Microbiota
- mTOR
- Nutrition
- Postnatal growth restriction
- Premature infant
- Pulmonary hypertension
ASJC Scopus subject areas
- Physiology
- Pharmacology
- Physiology (medical)
Cite this
Somatic growth and the risks of bronchopulmonary dysplasia and pulmonary hypertension : Connecting epidemiology and physiology 1. / Underwood, Mark; Wedgwood, Stephen; Lakshminrusimha, Satyanarayana; Steinhorn, Robin H.
In: Canadian Journal of Physiology and Pharmacology, Vol. 97, No. 3, 01.01.2019, p. 197-205.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Somatic growth and the risks of bronchopulmonary dysplasia and pulmonary hypertension
T2 - Connecting epidemiology and physiology 1
AU - Underwood, Mark
AU - Wedgwood, Stephen
AU - Lakshminrusimha, Satyanarayana
AU - Steinhorn, Robin H
PY - 2019/1/1
Y1 - 2019/1/1
N2 - In the premature infant, poor growth in utero (fetal growth restriction) and in the first weeks of life (postnatal growth restriction) are associated with increased risk for bronchopulmonary dysplasia and pulmonary hypertension. In this review, we summarize the epidemiologic data supporting these associations, present a novel rodent model of postnatal growth restriction, and review 5 promising mechanisms by which poor nutrition may affect the developing lung. These observations support the hypothesis that nutritional and (or) pharmacologic interventions early in life may be able to decrease risk of the pulmonary complications of extreme prematurity.
AB - In the premature infant, poor growth in utero (fetal growth restriction) and in the first weeks of life (postnatal growth restriction) are associated with increased risk for bronchopulmonary dysplasia and pulmonary hypertension. In this review, we summarize the epidemiologic data supporting these associations, present a novel rodent model of postnatal growth restriction, and review 5 promising mechanisms by which poor nutrition may affect the developing lung. These observations support the hypothesis that nutritional and (or) pharmacologic interventions early in life may be able to decrease risk of the pulmonary complications of extreme prematurity.
KW - Bronchopulmonary dysplasia
KW - Dyslipidemia
KW - Fetal growth restriction
KW - Inflammation
KW - Microbiota
KW - mTOR
KW - Nutrition
KW - Postnatal growth restriction
KW - Premature infant
KW - Pulmonary hypertension
UR - http://www.scopus.com/inward/record.url?scp=85062426989&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85062426989&partnerID=8YFLogxK
U2 - 10.1139/cjpp-2018-0386
DO - 10.1139/cjpp-2018-0386
M3 - Review article
VL - 97
SP - 197
EP - 205
JO - Canadian Journal of Physiology and Pharmacology
JF - Canadian Journal of Physiology and Pharmacology
SN - 0008-4212
IS - 3
ER -