Somatic growth and the risks of bronchopulmonary dysplasia and pulmonary hypertension: Connecting epidemiology and physiology 1

Mark Underwood, Stephen Wedgwood, Satyanarayana Lakshminrusimha, Robin H Steinhorn

Research output: Contribution to journalReview article

Abstract

In the premature infant, poor growth in utero (fetal growth restriction) and in the first weeks of life (postnatal growth restriction) are associated with increased risk for bronchopulmonary dysplasia and pulmonary hypertension. In this review, we summarize the epidemiologic data supporting these associations, present a novel rodent model of postnatal growth restriction, and review 5 promising mechanisms by which poor nutrition may affect the developing lung. These observations support the hypothesis that nutritional and (or) pharmacologic interventions early in life may be able to decrease risk of the pulmonary complications of extreme prematurity.

Original languageEnglish (US)
Pages (from-to)197-205
Number of pages9
JournalCanadian Journal of Physiology and Pharmacology
Volume97
Issue number3
DOIs
StatePublished - Jan 1 2019

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Keywords

  • Bronchopulmonary dysplasia
  • Dyslipidemia
  • Fetal growth restriction
  • Inflammation
  • Microbiota
  • mTOR
  • Nutrition
  • Postnatal growth restriction
  • Premature infant
  • Pulmonary hypertension

ASJC Scopus subject areas

  • Physiology
  • Pharmacology
  • Physiology (medical)

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