Solution-phase synthesis of a 1,5-dialkylamino-2,4-dinitrobenzene library and the identification of novel antibacterial compounds from this library

Gang Liu, Yemei Fan, James R. Carlson, Zhan Gong Zhao, Kit Lam

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

In this report we demonstrate that a 1,5-dialkylamino-2,4-dinitrobenzene small molecule library can be generated by a highly efficient solution-phase synthesis method. From this 2485-member library, a series of novel compounds with antibacterial activity were isolated. The significance of this report is that the synthetic scheme is extremely simple, with minimal number of liquid handling steps, and the solvents and reagents left in the final library preparation are fully compatible with cell-based assays.

Original languageEnglish (US)
Pages (from-to)467-474
Number of pages8
JournalJournal of Combinatorial Chemistry
Volume2
Issue number5
StatePublished - Sep 2000

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Libraries
Synthesis
Small Molecule Libraries
Efficient Solution
Assays
Preparation
Molecules
Liquid
Series
Cell
Liquids
Demonstrate
2,4-dinitrobenzene

ASJC Scopus subject areas

  • Chemistry(all)
  • Organic Chemistry
  • Discrete Mathematics and Combinatorics
  • Drug Discovery

Cite this

Solution-phase synthesis of a 1,5-dialkylamino-2,4-dinitrobenzene library and the identification of novel antibacterial compounds from this library. / Liu, Gang; Fan, Yemei; Carlson, James R.; Zhao, Zhan Gong; Lam, Kit.

In: Journal of Combinatorial Chemistry, Vol. 2, No. 5, 09.2000, p. 467-474.

Research output: Contribution to journalArticle

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