Solution-Phase Hexasaccharide Synthesis Using Glucosyl Iodides

Son N. Lam; Jacquelyn Gervay-Hague

doi:10.1021/ol025887d

Solution-Phase Hexasaccharide Synthesis Using Glucosyl Iodides

Son N. Lam, Jacquelyn Gervay-Hague

Chemistry

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63 Scopus citations

Abstract

(Equation Presented) Oligosaccharides composed of 1,6-glucosyl residues have been prepared from glucosyl iodides. The reactions are highly stereoselective, giving the α-glycosides as the only isolated products in yields ranging from 84% to 94%. Oligomer synthesis can take place in an iterative 1 + 1 + 1 fashion or in a convergent manner where dimer iodides serve as donors for higher order acceptors.

Original language	English (US)
Pages (from-to)	2039-2042
Number of pages	4
Journal	Organic Letters
Volume	4
Issue number	12
DOIs	https://doi.org/10.1021/ol025887d
State	Published - Jun 13 2002

ASJC Scopus subject areas

Molecular Medicine

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abstract = "(Equation Presented) Oligosaccharides composed of 1,6-glucosyl residues have been prepared from glucosyl iodides. The reactions are highly stereoselective, giving the α-glycosides as the only isolated products in yields ranging from 84% to 94%. Oligomer synthesis can take place in an iterative 1 + 1 + 1 fashion or in a convergent manner where dimer iodides serve as donors for higher order acceptors.",

author = "Lam, {Son N.} and Jacquelyn Gervay-Hague",

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N2 - (Equation Presented) Oligosaccharides composed of 1,6-glucosyl residues have been prepared from glucosyl iodides. The reactions are highly stereoselective, giving the α-glycosides as the only isolated products in yields ranging from 84% to 94%. Oligomer synthesis can take place in an iterative 1 + 1 + 1 fashion or in a convergent manner where dimer iodides serve as donors for higher order acceptors.

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Solution-Phase Hexasaccharide Synthesis Using Glucosyl Iodides

Abstract

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