Soluble epoxide hydrolase inhibition reveals novel biological functions of epoxyeicosatrienoic acids (EETs)

Bora Inceoglu, Kara R. Schmelzer, Christophe Morisseau, Steve L. Jinks, Bruce D. Hammock

Research output: Contribution to journalArticle

143 Citations (Scopus)

Abstract

Early on, intriguing biological activities were found associated with the EETs using in vitro systems. Although the EETs other than the 5,6-isomer, are quite stable chemically, they are quickly degraded enzymatically with the sEH accounting in many cases for much of the metabolism. This rapid degradation often made it difficult to associate biological effects with the administration of EETs and other lipid epoxides particularly in vivo. Thus, it is the power to inhibit the sEH that has facilitated the demonstration of many physiological processes associated with EETs and possibly other epoxy fatty acids. In the last few years it has become clear that major roles of the EETs include modulation of blood pressure and modulation of inflammatory cascades. There are a number of other physiological functions now associated with the EETs including angiogenesis, neurohormone release, cell proliferation, G protein signaling, modulation of ion channel activity, and a variety of effects associated with modulation of NFκB. More recently we observed a role of the EETs as modulated by sEHI in reducing non-neuropathic pain. The array of biological effects observed with sEHI illustrates the power of modulating the degradation of chemical mediators in addition to the modulation of their biosynthesis, receptor binding and signal transduction. Many of these biological effects can be modulated by sEHIs but also by the natural eicosanoids and their mimics all of which offer therapeutic potential.

Original languageEnglish (US)
Pages (from-to)42-49
Number of pages8
JournalProstaglandins and Other Lipid Mediators
Volume82
Issue number1-4
DOIs
StatePublished - Jan 2007

Fingerprint

Epoxide Hydrolases
Modulation
Physiological Phenomena
Acids
Eicosanoids
Epoxy Compounds
Ion Channels
GTP-Binding Proteins
Neurotransmitter Agents
Signal Transduction
Fatty Acids
Cell Proliferation
Blood Pressure
Lipids
Pain
Degradation
Signal transduction
Biosynthesis
Blood pressure
Cell proliferation

Keywords

  • Arachidonic acid
  • COX
  • Epoxyeicosatrienoic acid
  • Hyperalgesia
  • Inhibitor
  • Nociception
  • sEH

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

Cite this

Soluble epoxide hydrolase inhibition reveals novel biological functions of epoxyeicosatrienoic acids (EETs). / Inceoglu, Bora; Schmelzer, Kara R.; Morisseau, Christophe; Jinks, Steve L.; Hammock, Bruce D.

In: Prostaglandins and Other Lipid Mediators, Vol. 82, No. 1-4, 01.2007, p. 42-49.

Research output: Contribution to journalArticle

Inceoglu, Bora ; Schmelzer, Kara R. ; Morisseau, Christophe ; Jinks, Steve L. ; Hammock, Bruce D. / Soluble epoxide hydrolase inhibition reveals novel biological functions of epoxyeicosatrienoic acids (EETs). In: Prostaglandins and Other Lipid Mediators. 2007 ; Vol. 82, No. 1-4. pp. 42-49.
@article{72e9a9573c2d4e0191ef922bd80429c1,
title = "Soluble epoxide hydrolase inhibition reveals novel biological functions of epoxyeicosatrienoic acids (EETs)",
abstract = "Early on, intriguing biological activities were found associated with the EETs using in vitro systems. Although the EETs other than the 5,6-isomer, are quite stable chemically, they are quickly degraded enzymatically with the sEH accounting in many cases for much of the metabolism. This rapid degradation often made it difficult to associate biological effects with the administration of EETs and other lipid epoxides particularly in vivo. Thus, it is the power to inhibit the sEH that has facilitated the demonstration of many physiological processes associated with EETs and possibly other epoxy fatty acids. In the last few years it has become clear that major roles of the EETs include modulation of blood pressure and modulation of inflammatory cascades. There are a number of other physiological functions now associated with the EETs including angiogenesis, neurohormone release, cell proliferation, G protein signaling, modulation of ion channel activity, and a variety of effects associated with modulation of NFκB. More recently we observed a role of the EETs as modulated by sEHI in reducing non-neuropathic pain. The array of biological effects observed with sEHI illustrates the power of modulating the degradation of chemical mediators in addition to the modulation of their biosynthesis, receptor binding and signal transduction. Many of these biological effects can be modulated by sEHIs but also by the natural eicosanoids and their mimics all of which offer therapeutic potential.",
keywords = "Arachidonic acid, COX, Epoxyeicosatrienoic acid, Hyperalgesia, Inhibitor, Nociception, sEH",
author = "Bora Inceoglu and Schmelzer, {Kara R.} and Christophe Morisseau and Jinks, {Steve L.} and Hammock, {Bruce D.}",
year = "2007",
month = "1",
doi = "10.1016/j.prostaglandins.2006.05.004",
language = "English (US)",
volume = "82",
pages = "42--49",
journal = "Prostaglandins and Other Lipid Mediators",
issn = "1098-8823",
publisher = "Elsevier Inc.",
number = "1-4",

}

TY - JOUR

T1 - Soluble epoxide hydrolase inhibition reveals novel biological functions of epoxyeicosatrienoic acids (EETs)

AU - Inceoglu, Bora

AU - Schmelzer, Kara R.

AU - Morisseau, Christophe

AU - Jinks, Steve L.

AU - Hammock, Bruce D.

PY - 2007/1

Y1 - 2007/1

N2 - Early on, intriguing biological activities were found associated with the EETs using in vitro systems. Although the EETs other than the 5,6-isomer, are quite stable chemically, they are quickly degraded enzymatically with the sEH accounting in many cases for much of the metabolism. This rapid degradation often made it difficult to associate biological effects with the administration of EETs and other lipid epoxides particularly in vivo. Thus, it is the power to inhibit the sEH that has facilitated the demonstration of many physiological processes associated with EETs and possibly other epoxy fatty acids. In the last few years it has become clear that major roles of the EETs include modulation of blood pressure and modulation of inflammatory cascades. There are a number of other physiological functions now associated with the EETs including angiogenesis, neurohormone release, cell proliferation, G protein signaling, modulation of ion channel activity, and a variety of effects associated with modulation of NFκB. More recently we observed a role of the EETs as modulated by sEHI in reducing non-neuropathic pain. The array of biological effects observed with sEHI illustrates the power of modulating the degradation of chemical mediators in addition to the modulation of their biosynthesis, receptor binding and signal transduction. Many of these biological effects can be modulated by sEHIs but also by the natural eicosanoids and their mimics all of which offer therapeutic potential.

AB - Early on, intriguing biological activities were found associated with the EETs using in vitro systems. Although the EETs other than the 5,6-isomer, are quite stable chemically, they are quickly degraded enzymatically with the sEH accounting in many cases for much of the metabolism. This rapid degradation often made it difficult to associate biological effects with the administration of EETs and other lipid epoxides particularly in vivo. Thus, it is the power to inhibit the sEH that has facilitated the demonstration of many physiological processes associated with EETs and possibly other epoxy fatty acids. In the last few years it has become clear that major roles of the EETs include modulation of blood pressure and modulation of inflammatory cascades. There are a number of other physiological functions now associated with the EETs including angiogenesis, neurohormone release, cell proliferation, G protein signaling, modulation of ion channel activity, and a variety of effects associated with modulation of NFκB. More recently we observed a role of the EETs as modulated by sEHI in reducing non-neuropathic pain. The array of biological effects observed with sEHI illustrates the power of modulating the degradation of chemical mediators in addition to the modulation of their biosynthesis, receptor binding and signal transduction. Many of these biological effects can be modulated by sEHIs but also by the natural eicosanoids and their mimics all of which offer therapeutic potential.

KW - Arachidonic acid

KW - COX

KW - Epoxyeicosatrienoic acid

KW - Hyperalgesia

KW - Inhibitor

KW - Nociception

KW - sEH

UR - http://www.scopus.com/inward/record.url?scp=33845347545&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33845347545&partnerID=8YFLogxK

U2 - 10.1016/j.prostaglandins.2006.05.004

DO - 10.1016/j.prostaglandins.2006.05.004

M3 - Article

C2 - 17164131

AN - SCOPUS:33845347545

VL - 82

SP - 42

EP - 49

JO - Prostaglandins and Other Lipid Mediators

JF - Prostaglandins and Other Lipid Mediators

SN - 1098-8823

IS - 1-4

ER -