Soluble epoxide hydrolase as a therapeutic target for cardiovascular diseases

John D. Imig, Bruce D. Hammock

Research output: Contribution to journalArticle

384 Scopus citations

Abstract

The cardiovascular effects of epoxyeicosatrienoic acids (EETs) include vasodilation, antimigratory actions on vascular smooth muscle cells and anti-inflammatory actions. These endogenous lipid mediators are broken down into diols by soluble epoxide hydrolase (sEH), and so inhibiting this enzyme would be expected to enhance the beneficial cardiovascular properties of EETs. sEH inhibitors (sEHIs) that are based on 1,3-disubstituted urea have been rapidly developed, and have been shown to be antihypertensive and anti-inflammatory, and to protect the brain, heart and kidney from damage. Although challenges for the future exist - including improving the drug-like properties of sEHIs and finding better ways to target sEHIs to specific tissues - the recent initiation of the first clinical trials of sEHIs has highlighted the therapeutic potential of these agents.

Original languageEnglish (US)
Pages (from-to)794-805
Number of pages12
JournalNature Reviews Drug Discovery
Volume8
Issue number10
DOIs
StatePublished - 2009

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology

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