Soluble CD14 and fracture risk

M. Bethel, P. Bůžková, H. A. Fink, John A Robbins, J. A. Cauley, J. Lee, J. I. Barzilay, D. I. Jalal, L. D. Carbone

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Summary: Soluble CD14 (sCD14) is an inflammatory marker associated with osteoclasts. Using Cox proportional hazards models, we found a positive association between plasma levels of sCD14 and risk of incident fracture among participants in the Cardiovascular Health Study. sCD14 may be useful in identifying those at risk for fracture. Introduction: Soluble CD14, a proinflammatory cytokine, is primarily derived from macrophages/monocytes that can differentiate into osteoclasts. The purpose of this study was to examine the relationship between sCD14 levels and osteoporotic fractures. Methods: In the Cardiovascular Health Study, 5462 men and women had sCD14 levels measured at baseline. Incident hip fractures (median follow-up time 12.5 years) and incident composite fractures (defined as the first hip, pelvis, humerus, or distal radius fracture, median follow-up 8.6 years) were identified from hospital discharge summaries and/or Medicare claims data. Cox proportional hazards models were used to model the association between sCD14 levels and time to incident hip or composite fracture, overall and as a function of race and gender. Results: In unadjusted models, there was a positive association between sCD14 levels (per 1 standard deviation increase, i.e., 361.6 ng/mL) and incident hip (HR, 1.26; 95 % CI, 1.17, 1.36) and composite (HR, 1.20; 95 % CI, 1.12, 1.28) fractures. When models were fully adjusted for demographics, lifestyle factors, and medication use, these associations were no longer significant. However, in whites, the association of sCD14 levels with hip fractures remained significant in fully adjusted models (HR, 1.11; 95 % CI, 1.01–1.23). Associations of sCD14 levels with hip and composite fracture did not differ between men and women. Conclusions: In this large cohort of community-dwelling older adults, higher sCD14 levels were associated with an increased risk of incident hip fractures in whites.

Original languageEnglish (US)
Pages (from-to)1755-1763
Number of pages9
JournalOsteoporosis International
Volume27
Issue number5
DOIs
StatePublished - May 1 2016

Fingerprint

Hip Fractures
Hip
Osteoclasts
Proportional Hazards Models
Independent Living
Radius Fractures
Osteoporotic Fractures
Humerus
Health
Medicare
Pelvis
Life Style
Macrophages
Demography
Cytokines

Keywords

  • Epidemiology
  • Fracture
  • Inflammatory markers
  • Osteoporosis

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

Cite this

Bethel, M., Bůžková, P., Fink, H. A., Robbins, J. A., Cauley, J. A., Lee, J., ... Carbone, L. D. (2016). Soluble CD14 and fracture risk. Osteoporosis International, 27(5), 1755-1763. https://doi.org/10.1007/s00198-015-3439-9

Soluble CD14 and fracture risk. / Bethel, M.; Bůžková, P.; Fink, H. A.; Robbins, John A; Cauley, J. A.; Lee, J.; Barzilay, J. I.; Jalal, D. I.; Carbone, L. D.

In: Osteoporosis International, Vol. 27, No. 5, 01.05.2016, p. 1755-1763.

Research output: Contribution to journalArticle

Bethel, M, Bůžková, P, Fink, HA, Robbins, JA, Cauley, JA, Lee, J, Barzilay, JI, Jalal, DI & Carbone, LD 2016, 'Soluble CD14 and fracture risk', Osteoporosis International, vol. 27, no. 5, pp. 1755-1763. https://doi.org/10.1007/s00198-015-3439-9
Bethel M, Bůžková P, Fink HA, Robbins JA, Cauley JA, Lee J et al. Soluble CD14 and fracture risk. Osteoporosis International. 2016 May 1;27(5):1755-1763. https://doi.org/10.1007/s00198-015-3439-9
Bethel, M. ; Bůžková, P. ; Fink, H. A. ; Robbins, John A ; Cauley, J. A. ; Lee, J. ; Barzilay, J. I. ; Jalal, D. I. ; Carbone, L. D. / Soluble CD14 and fracture risk. In: Osteoporosis International. 2016 ; Vol. 27, No. 5. pp. 1755-1763.
@article{2c3aac05a2c14d0ebc68eb55732aa8d2,
title = "Soluble CD14 and fracture risk",
abstract = "Summary: Soluble CD14 (sCD14) is an inflammatory marker associated with osteoclasts. Using Cox proportional hazards models, we found a positive association between plasma levels of sCD14 and risk of incident fracture among participants in the Cardiovascular Health Study. sCD14 may be useful in identifying those at risk for fracture. Introduction: Soluble CD14, a proinflammatory cytokine, is primarily derived from macrophages/monocytes that can differentiate into osteoclasts. The purpose of this study was to examine the relationship between sCD14 levels and osteoporotic fractures. Methods: In the Cardiovascular Health Study, 5462 men and women had sCD14 levels measured at baseline. Incident hip fractures (median follow-up time 12.5 years) and incident composite fractures (defined as the first hip, pelvis, humerus, or distal radius fracture, median follow-up 8.6 years) were identified from hospital discharge summaries and/or Medicare claims data. Cox proportional hazards models were used to model the association between sCD14 levels and time to incident hip or composite fracture, overall and as a function of race and gender. Results: In unadjusted models, there was a positive association between sCD14 levels (per 1 standard deviation increase, i.e., 361.6 ng/mL) and incident hip (HR, 1.26; 95 {\%} CI, 1.17, 1.36) and composite (HR, 1.20; 95 {\%} CI, 1.12, 1.28) fractures. When models were fully adjusted for demographics, lifestyle factors, and medication use, these associations were no longer significant. However, in whites, the association of sCD14 levels with hip fractures remained significant in fully adjusted models (HR, 1.11; 95 {\%} CI, 1.01–1.23). Associations of sCD14 levels with hip and composite fracture did not differ between men and women. Conclusions: In this large cohort of community-dwelling older adults, higher sCD14 levels were associated with an increased risk of incident hip fractures in whites.",
keywords = "Epidemiology, Fracture, Inflammatory markers, Osteoporosis",
author = "M. Bethel and P. Bůžkov{\'a} and Fink, {H. A.} and Robbins, {John A} and Cauley, {J. A.} and J. Lee and Barzilay, {J. I.} and Jalal, {D. I.} and Carbone, {L. D.}",
year = "2016",
month = "5",
day = "1",
doi = "10.1007/s00198-015-3439-9",
language = "English (US)",
volume = "27",
pages = "1755--1763",
journal = "Osteoporosis International",
issn = "0937-941X",
publisher = "Springer London",
number = "5",

}

TY - JOUR

T1 - Soluble CD14 and fracture risk

AU - Bethel, M.

AU - Bůžková, P.

AU - Fink, H. A.

AU - Robbins, John A

AU - Cauley, J. A.

AU - Lee, J.

AU - Barzilay, J. I.

AU - Jalal, D. I.

AU - Carbone, L. D.

PY - 2016/5/1

Y1 - 2016/5/1

N2 - Summary: Soluble CD14 (sCD14) is an inflammatory marker associated with osteoclasts. Using Cox proportional hazards models, we found a positive association between plasma levels of sCD14 and risk of incident fracture among participants in the Cardiovascular Health Study. sCD14 may be useful in identifying those at risk for fracture. Introduction: Soluble CD14, a proinflammatory cytokine, is primarily derived from macrophages/monocytes that can differentiate into osteoclasts. The purpose of this study was to examine the relationship between sCD14 levels and osteoporotic fractures. Methods: In the Cardiovascular Health Study, 5462 men and women had sCD14 levels measured at baseline. Incident hip fractures (median follow-up time 12.5 years) and incident composite fractures (defined as the first hip, pelvis, humerus, or distal radius fracture, median follow-up 8.6 years) were identified from hospital discharge summaries and/or Medicare claims data. Cox proportional hazards models were used to model the association between sCD14 levels and time to incident hip or composite fracture, overall and as a function of race and gender. Results: In unadjusted models, there was a positive association between sCD14 levels (per 1 standard deviation increase, i.e., 361.6 ng/mL) and incident hip (HR, 1.26; 95 % CI, 1.17, 1.36) and composite (HR, 1.20; 95 % CI, 1.12, 1.28) fractures. When models were fully adjusted for demographics, lifestyle factors, and medication use, these associations were no longer significant. However, in whites, the association of sCD14 levels with hip fractures remained significant in fully adjusted models (HR, 1.11; 95 % CI, 1.01–1.23). Associations of sCD14 levels with hip and composite fracture did not differ between men and women. Conclusions: In this large cohort of community-dwelling older adults, higher sCD14 levels were associated with an increased risk of incident hip fractures in whites.

AB - Summary: Soluble CD14 (sCD14) is an inflammatory marker associated with osteoclasts. Using Cox proportional hazards models, we found a positive association between plasma levels of sCD14 and risk of incident fracture among participants in the Cardiovascular Health Study. sCD14 may be useful in identifying those at risk for fracture. Introduction: Soluble CD14, a proinflammatory cytokine, is primarily derived from macrophages/monocytes that can differentiate into osteoclasts. The purpose of this study was to examine the relationship between sCD14 levels and osteoporotic fractures. Methods: In the Cardiovascular Health Study, 5462 men and women had sCD14 levels measured at baseline. Incident hip fractures (median follow-up time 12.5 years) and incident composite fractures (defined as the first hip, pelvis, humerus, or distal radius fracture, median follow-up 8.6 years) were identified from hospital discharge summaries and/or Medicare claims data. Cox proportional hazards models were used to model the association between sCD14 levels and time to incident hip or composite fracture, overall and as a function of race and gender. Results: In unadjusted models, there was a positive association between sCD14 levels (per 1 standard deviation increase, i.e., 361.6 ng/mL) and incident hip (HR, 1.26; 95 % CI, 1.17, 1.36) and composite (HR, 1.20; 95 % CI, 1.12, 1.28) fractures. When models were fully adjusted for demographics, lifestyle factors, and medication use, these associations were no longer significant. However, in whites, the association of sCD14 levels with hip fractures remained significant in fully adjusted models (HR, 1.11; 95 % CI, 1.01–1.23). Associations of sCD14 levels with hip and composite fracture did not differ between men and women. Conclusions: In this large cohort of community-dwelling older adults, higher sCD14 levels were associated with an increased risk of incident hip fractures in whites.

KW - Epidemiology

KW - Fracture

KW - Inflammatory markers

KW - Osteoporosis

UR - http://www.scopus.com/inward/record.url?scp=84949650061&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84949650061&partnerID=8YFLogxK

U2 - 10.1007/s00198-015-3439-9

DO - 10.1007/s00198-015-3439-9

M3 - Article

VL - 27

SP - 1755

EP - 1763

JO - Osteoporosis International

JF - Osteoporosis International

SN - 0937-941X

IS - 5

ER -