Lebend-Organspende in der isolierten Pankreas- und simultanen Pankreas-Nieren-Transplantation

Translated title of the contribution: Solitary pancreas and simultaneous pancreas-kidney transplantation from living donors

Christoph Troppmann, A. C. Grüssner, D. E R Sutherland, R. W G Grüssner

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

We studied retrospectively 106 pancreas transplants from living donors. Of these, 83 were solitary pancreas transplants, done between June 1979 and December 1997 (51 pancreas transplants alone for non-uremic recipients as well as 32 pancreas-after-kidney transplants for previously uremic recipients with a functioning kidney graft), and 23 were simultaneous pancreas-kidney transplants (SPK), done between March 1994 and December 1997. In all, 105 (99%) donors were genetically related to the recipients. Perioperative donor mortality was O%. Donor complications included 9 splenectomies as well as 4 operatively drained and 7 percutaneously managed peripancreatic fluid collections. We noted hyperglycemia in 3 (3%) donors (all among the initial cases in this series). The 1-year graft survival rate was 50% for solitary pancreas recipients and 78% (pancreas) and 100% (kidney) for SPK recipients. Of the 5 pancreas graft losses which occurred after SPK, 3 were due to thrombosis, 1 to pancreatitis and infection, and 1 to chronic rejection. Currently, all kidney grafts and 18 pancreas grafts are functioning in these 23 dual organ recipients (with O% recipient mortality). Living donor pancreas and SPK grafting is associated with low donor morbidity and good graft outcome. With stringent donor criteria and appropriate counseling of the prospective donor/recipient pairs, living donor pancreas transplants may become a more widely applied therapeutic alternative for selected non-uremic and uremic patients with Type I diabetes.

Original languageGerman
Pages (from-to)734-738
Number of pages5
JournalZentralblatt fur Chirurgie
Volume124
Issue number8
StatePublished - 1999
Externally publishedYes

    Fingerprint

Keywords

  • Kidney transplantation
  • Living donor
  • Pancreas transplantation
  • Rejection
  • Type I insulin-dependent diabetes mellitus

ASJC Scopus subject areas

  • Surgery

Cite this

Troppmann, C., Grüssner, A. C., Sutherland, D. E. R., & Grüssner, R. W. G. (1999). Lebend-Organspende in der isolierten Pankreas- und simultanen Pankreas-Nieren-Transplantation. Zentralblatt fur Chirurgie, 124(8), 734-738.