Solid phase synthesis of [18F]labelled peptides for positron emission tomography

Julie Sutcliffe, Michael J. O'Doherty, Sukhvinder S. Bansal

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

A strategy for the solid phase synthesis of [18F]labelled peptides has been developed. The peptides were prepared on solid support and acylated with 4-[18F]fluorobenzoic acid using HATU within 3 min and the labelled peptide was released from the solid support within 7 min. The [18F]labelled peptides were produced in good purity with a specific activity of 20-25 GBq/μmol. (C) 2000 Elsevier Science Ltd. All rights reserved.

Original languageEnglish (US)
Pages (from-to)1501-1503
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume10
Issue number14
DOIs
StatePublished - Jul 17 2000
Externally publishedYes

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Solid-Phase Synthesis Techniques
Positron emission tomography
Positron-Emission Tomography
Peptides
Acids

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Solid phase synthesis of [18F]labelled peptides for positron emission tomography. / Sutcliffe, Julie; O'Doherty, Michael J.; Bansal, Sukhvinder S.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 10, No. 14, 17.07.2000, p. 1501-1503.

Research output: Contribution to journalArticle

Sutcliffe, Julie ; O'Doherty, Michael J. ; Bansal, Sukhvinder S. / Solid phase synthesis of [18F]labelled peptides for positron emission tomography. In: Bioorganic and Medicinal Chemistry Letters. 2000 ; Vol. 10, No. 14. pp. 1501-1503.
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