Solid phase synthesis of [18F]labelled peptides for positron emission tomography

Julie Sutcliffe; Michael J. O'Doherty; Sukhvinder S. Bansal

doi:10.1016/S0960-894X(00)00179-7

Solid phase synthesis of [¹⁸F]labelled peptides for positron emission tomography

Julie Sutcliffe, Michael J. O'Doherty, Sukhvinder S. Bansal

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

A strategy for the solid phase synthesis of [¹⁸F]labelled peptides has been developed. The peptides were prepared on solid support and acylated with 4-[¹⁸F]fluorobenzoic acid using HATU within 3 min and the labelled peptide was released from the solid support within 7 min. The [¹⁸F]labelled peptides were produced in good purity with a specific activity of 20-25 GBq/μmol. (C) 2000 Elsevier Science Ltd. All rights reserved.

Original language	English (US)
Pages (from-to)	1501-1503
Number of pages	3
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	10
Issue number	14
DOIs	https://doi.org/10.1016/S0960-894X(00)00179-7
State	Published - Jul 17 2000
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Organic Chemistry
Drug Discovery
Pharmaceutical Science

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10.1016/S0960-894X(00)00179-7

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AB - A strategy for the solid phase synthesis of [18F]labelled peptides has been developed. The peptides were prepared on solid support and acylated with 4-[18F]fluorobenzoic acid using HATU within 3 min and the labelled peptide was released from the solid support within 7 min. The [18F]labelled peptides were produced in good purity with a specific activity of 20-25 GBq/μmol. (C) 2000 Elsevier Science Ltd. All rights reserved.

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Solid phase synthesis of [¹⁸F]labelled peptides for positron emission tomography

Abstract

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