Abstract
A strategy for the solid phase synthesis of [18F]labelled peptides has been developed. The peptides were prepared on solid support and acylated with 4-[18F]fluorobenzoic acid using HATU within 3 min and the labelled peptide was released from the solid support within 7 min. The [18F]labelled peptides were produced in good purity with a specific activity of 20-25 GBq/μmol. (C) 2000 Elsevier Science Ltd. All rights reserved.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1501-1503 |
| Number of pages | 3 |
| Journal | Bioorganic and Medicinal Chemistry Letters |
| Volume | 10 |
| Issue number | 14 |
| DOIs | |
| State | Published - Jul 17 2000 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Organic Chemistry
- Drug Discovery
- Pharmaceutical Science
Cite this
Solid phase synthesis of [18F]labelled peptides for positron emission tomography. / Sutcliffe, Julie; O'Doherty, Michael J.; Bansal, Sukhvinder S.
In: Bioorganic and Medicinal Chemistry Letters, Vol. 10, No. 14, 17.07.2000, p. 1501-1503.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Solid phase synthesis of [18F]labelled peptides for positron emission tomography
AU - Sutcliffe, Julie
AU - O'Doherty, Michael J.
AU - Bansal, Sukhvinder S.
PY - 2000/7/17
Y1 - 2000/7/17
N2 - A strategy for the solid phase synthesis of [18F]labelled peptides has been developed. The peptides were prepared on solid support and acylated with 4-[18F]fluorobenzoic acid using HATU within 3 min and the labelled peptide was released from the solid support within 7 min. The [18F]labelled peptides were produced in good purity with a specific activity of 20-25 GBq/μmol. (C) 2000 Elsevier Science Ltd. All rights reserved.
AB - A strategy for the solid phase synthesis of [18F]labelled peptides has been developed. The peptides were prepared on solid support and acylated with 4-[18F]fluorobenzoic acid using HATU within 3 min and the labelled peptide was released from the solid support within 7 min. The [18F]labelled peptides were produced in good purity with a specific activity of 20-25 GBq/μmol. (C) 2000 Elsevier Science Ltd. All rights reserved.
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UR - http://www.scopus.com/inward/citedby.url?scp=0034679765&partnerID=8YFLogxK
U2 - 10.1016/S0960-894X(00)00179-7
DO - 10.1016/S0960-894X(00)00179-7
M3 - Article
VL - 10
SP - 1501
EP - 1503
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
SN - 0960-894X
IS - 14
ER -