Solid-phase synthesis of O-glycosylated Nα-Fmoc amino acids and analysis by high-resolution magic angle spinning NMR

Nian Huan Yao, Wen Yi He, Kit Lam, Gang Liu

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Direct O-glycosylation of amino acids bound to TentaGel resin with a number of glycosyl trichloroacetimidate donors results in high yields. The glycosylation reaction can be easily monitored by analyzing the bead-bound amino acids with high-resolution magic angle spinning (HR-MAS) NMR. These studies pave a new way for the construction of "one-bead one-compound" O-glycopeptide libraries with standard amino acid building blocks and appropriate glycosyl trichloroacetimidate donors.

Original languageEnglish (US)
Pages (from-to)214-219
Number of pages6
JournalJournal of Combinatorial Chemistry
Volume6
Issue number2
DOIs
StatePublished - Mar 2004

Fingerprint

Solid-Phase Synthesis Techniques
Magic angle spinning
Glycosylation
Amino Acids
High Resolution
Nuclear magnetic resonance
Synthesis
Angle
Glycopeptides
Building Blocks
trichloroacetamide

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Chemistry(all)
  • Discrete Mathematics and Combinatorics

Cite this

Solid-phase synthesis of O-glycosylated Nα-Fmoc amino acids and analysis by high-resolution magic angle spinning NMR. / Yao, Nian Huan; He, Wen Yi; Lam, Kit; Liu, Gang.

In: Journal of Combinatorial Chemistry, Vol. 6, No. 2, 03.2004, p. 214-219.

Research output: Contribution to journalArticle

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