Solid-phase synthesis of acridine-peptide conjugates and their analysis by tandem mass spectrometry

Coby B. Carlson, Peter A. Beal

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

(Matrix presented) A novel and high-yielding synthesis of 9-anilinoacridine-4-carboxylic acid is reported. This acid has been used in the solid-phase synthesis of a small combinatorial library of acridine-peptide conjugates. Tandem mass spectrometry (ES-MS/MS) can be used for structure determination of these compounds at a sensitivity of ∼10 pmol. This work makes possible the generation of acridine-peptide libraries for the discovery of structure-specific nucleic acid ligands via affinity chromatography selection with mass spectrometric detection.

Original languageEnglish (US)
Pages (from-to)1465-1468
Number of pages4
JournalOrganic Letters
Volume2
Issue number10
StatePublished - May 18 2000
Externally publishedYes

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ASJC Scopus subject areas

  • Molecular Medicine

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