Solid-phase synthesis of acridine-based threading intercalator peptides

Coby B. Carlson, Peter A. Beal

Research output: Contribution to journalArticle

44 Scopus citations

Abstract

The preparation of a novel acridine-based amino acid is reported. This N-Alloc-protected monomer can be coupled and deprotected under solid-phase peptide synthesis procedures to create acridine-peptide conjugates as potential threading intercalators. A peptide containing this novel amino acid undergoes spectral changes in the presence of duplex DNA and RNA consistent with intercalative binding. (C) 2000 Elsevier Science Ltd.

Original languageEnglish (US)
Pages (from-to)1979-1982
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume10
Issue number17
DOIs
StatePublished - Sep 4 2000
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

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