Abstract
A solid phase strategy has been developed for the synthesis of 3-(5-arylpyridin-2-yl)-4-hydroxycoumarins. The key transformation is an intramolecular ipso substitution reaction which forms the coumarin heterocycle and culminates with cleavage of product from the polymer support. The pyridine moiety at C3 can be further modified with Suzuki coupling. A sample library with two diversity elements has been synthesized to demonstrate this ipso substation-based cyclo-elimination strategy.
Original language | English (US) |
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Pages (from-to) | 1985-1988 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 47 |
Issue number | 12 |
DOIs | |
State | Published - Mar 20 2006 |
ASJC Scopus subject areas
- Biochemistry
- Organic Chemistry
- Drug Discovery