Solid phase synthesis of 3-(5-arylpyridin-2-yl)-4-hydroxycoumarins

Yannan Liu, Aaron D. Mills, Mark J. Kurth

Research output: Contribution to journalArticle

12 Scopus citations


A solid phase strategy has been developed for the synthesis of 3-(5-arylpyridin-2-yl)-4-hydroxycoumarins. The key transformation is an intramolecular ipso substitution reaction which forms the coumarin heterocycle and culminates with cleavage of product from the polymer support. The pyridine moiety at C3 can be further modified with Suzuki coupling. A sample library with two diversity elements has been synthesized to demonstrate this ipso substation-based cyclo-elimination strategy.

Original languageEnglish (US)
Pages (from-to)1985-1988
Number of pages4
JournalTetrahedron Letters
Issue number12
StatePublished - Mar 20 2006


ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

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