Solid-phase synthesis and fluorine-18 radiolabeling of cycloRGDyK

Ryan A. Davis, Kevin Lau, Sven H. Hausner, Julie Sutcliffe

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Solid-phase peptide synthesis, head-to-tail cyclization, and subsequent radiolabeling provided a reproducible, simple, rapid synthetic method to generate the cyclic peptide radiotracer cRGDyK([18F]FBA). Herein is reported the first on-resin cyclization and 18F-radiolabeling of a cyclic peptide (cRGDyK) in an overall peptide synthesis yield of 88% (cRGDyK(NH2)) and subsequent radiolabeling yield of 14 ± 2% (decay corrected, n = 4). This approach is generally applicable to the development of an automated process for the synthesis of cyclic radiolabeled peptides for positron emission tomography (PET).

Original languageEnglish (US)
Pages (from-to)8659-8663
Number of pages5
JournalOrganic and Biomolecular Chemistry
Volume14
Issue number37
DOIs
StatePublished - 2016

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Solid-phase synthesis and fluorine-18 radiolabeling of cycloRGDyK'. Together they form a unique fingerprint.

  • Cite this