Solid-phase synthesis and antibacterial evaluations of N-demethylvancomycin derivatives

Nian Huan Yao, Gang Liu, Wen Yi He, Changqun Niu, James R. Carlson, Kit Lam

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Twenty-five N-demethylvancomycin derivatives were synthesized on solid-support and their structures were determined by LC-MS/MS. Biological evaluation of these compounds indicated that bulky hydrophobic substituent on vancosamine of N-demethylvancomycin can increase antibacterial activity against vancomycin-resistant Enterococcus faecalis.

Original languageEnglish (US)
Pages (from-to)2325-2329
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume15
Issue number9
DOIs
StatePublished - May 2 2005

Keywords

  • Demethylvancomycin derivatives
  • Solid-phase synthesis

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

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