Solid-phase combinatorial synthesis of polyisoxazolines: A two-reaction iterative protocol

Mark J. Kurth, Lisa A. Ahlberg Randall, Kazuya Takenouchi

Research output: Contribution to journalArticlepeer-review

52 Scopus citations


Starting from a polymer-bound olefin, iterative application of nitrile oxide 1,3-dipolar cycloaddition and selenide oxidation/elimination steps were employed to deliver a polymer-bound triisoxazoline that can be liberated from the resin by transesterification. When four nitroseleno ethers (2-5) and four capping nitroalkanes (6-9) were employed, a triisoxazoline library (V) of 64 positional isomers was obtained by three iterative applications of these two reactions. The tactical flexibility of this strategy for preparing small polyfunctional oligomers is particularly attractive in that each subunit addition proceeds via a C-C bond-forming step.

Original languageEnglish (US)
Pages (from-to)8755-8761
Number of pages7
JournalJournal of Organic Chemistry
Issue number25
StatePublished - Dec 13 1996

ASJC Scopus subject areas

  • Organic Chemistry


Dive into the research topics of 'Solid-phase combinatorial synthesis of polyisoxazolines: A two-reaction iterative protocol'. Together they form a unique fingerprint.

Cite this