Abstract
A 192-member library of N,N′-disubstituted urea inhibitors was synthesized by a solid-phase method. The ureas were tested for their inhibitory activities against recombinant human soluble epoxide hydrolase. Simple carbocyclic or para/meta-substituted phenyl groups showed inhibition potencies that were equal to or greater than adamantane-based sEH inhibitors, while the presence of bulky or ionizable groups close to the urea group dramatically decreased their activities.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 5773-5777 |
| Number of pages | 5 |
| Journal | Bioorganic and Medicinal Chemistry Letters |
| Volume | 16 |
| Issue number | 22 |
| DOIs | |
| State | Published - Nov 15 2006 |
Keywords
- Anti-inflammation
- Hypertension
- Soluble epoxide hydrolase
- Urea
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Organic Chemistry
- Drug Discovery
- Pharmaceutical Science
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Hwang, S. H., Morisseau, C., Do, Z., & Hammock, B. D. (2006). Solid-phase combinatorial approach for the optimization of soluble epoxide hydrolase inhibitors. Bioorganic and Medicinal Chemistry Letters, 16(22), 5773-5777. https://doi.org/10.1016/j.bmcl.2006.08.078