Solid-phase combinatorial approach for the optimization of soluble epoxide hydrolase inhibitors

Sung Hee Hwang, Christophe Morisseau, Zung Do, Bruce D. Hammock

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

A 192-member library of N,N′-disubstituted urea inhibitors was synthesized by a solid-phase method. The ureas were tested for their inhibitory activities against recombinant human soluble epoxide hydrolase. Simple carbocyclic or para/meta-substituted phenyl groups showed inhibition potencies that were equal to or greater than adamantane-based sEH inhibitors, while the presence of bulky or ionizable groups close to the urea group dramatically decreased their activities.

Original languageEnglish (US)
Pages (from-to)5773-5777
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume16
Issue number22
DOIs
StatePublished - Nov 15 2006

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Epoxide Hydrolases
Urea
Adamantane
Libraries

Keywords

  • Anti-inflammation
  • Hypertension
  • Soluble epoxide hydrolase
  • Urea

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Solid-phase combinatorial approach for the optimization of soluble epoxide hydrolase inhibitors. / Hwang, Sung Hee; Morisseau, Christophe; Do, Zung; Hammock, Bruce D.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 16, No. 22, 15.11.2006, p. 5773-5777.

Research output: Contribution to journalArticle

Hwang, Sung Hee ; Morisseau, Christophe ; Do, Zung ; Hammock, Bruce D. / Solid-phase combinatorial approach for the optimization of soluble epoxide hydrolase inhibitors. In: Bioorganic and Medicinal Chemistry Letters. 2006 ; Vol. 16, No. 22. pp. 5773-5777.
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