Sodium fluoride dissolution of human calcium oxalate/phosphate stone particles

Roger Low, S. Ho, M. L. Stoller

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The dissolutive effects of sodium fluoride on human calcium stone particles were investigated in an in vitro model. Stone particles composed of 65% calcium oxalate and 35% calcium phosphate dissolved in a dose-dependent fashion with NaF exposure. Stone particles exposed to 60 mM NaF had a 17% reduction in particle mass after 24 hours and a 62% reduction after 7 days in comparison with experimental controls bathed in physiologic normal saline. The systemic toxicity of the dose of oral fluoride necessary to achieve the optimal tested urinary concentrations would likely preclude oral administration, but NaF may have an adjunctive role in upper urinary tract irrigation for residual stone fragments after lithotripsy or in chronic low-dose oral administration for prophylaxis against recurrent calcium nephrolithiasis.

Original languageEnglish (US)
Pages (from-to)379-382
Number of pages4
JournalJournal of Endourology
Volume9
Issue number5
StatePublished - 1995

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Sodium Fluoride
Oral Administration
Calcium
Nephrolithiasis
Calcium Oxalate
Lithotripsy
Urinary Tract
Fluorides
calcium phosphate
In Vitro Techniques

ASJC Scopus subject areas

  • Urology

Cite this

Sodium fluoride dissolution of human calcium oxalate/phosphate stone particles. / Low, Roger; Ho, S.; Stoller, M. L.

In: Journal of Endourology, Vol. 9, No. 5, 1995, p. 379-382.

Research output: Contribution to journalArticle

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