Sodium cotransport in vascular smooth muscle cells

Martha E O'Donnell, N. E. Owen

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Vascular smooth muscle cells possess a number of Na cotransport systems. Three of these cotransport systems, Na/Ca exchange, Na/H exchange and Na-K-Cl cotransport, have been the subject of an increasing number of investigations to determine the respective roles of these transporters in vascular smooth muscle cell function. Evidence has been obtained that the Na/Ca exchange system participates in regulation of intracellular Ca in vascular smooth muscle cells. The Na/H exchange system appears to function in concert with a Cl/HCO3 exchange system to regulate intracellular pH. The Na-K-Cl cotransport system is a major contributor to K flux across the plasma membrane of vascular smooth muscle cells and is regulated by a number of vasoactive agents, suggesting that this Na cotransport system is also an important component of vascular smooth muscle cell function. Cultured vascular smooth muscle cells derived from spontaneously hypertensive rats have been found to exhibit reduced Na-K-Cl cotransport activity compared to smooth muscle cells from normotensive controls. Thus, alteration of vascular smooth muscle Na-K-Cl cotransport activity may be related to changes in vascular tone. However, the precise function of Na-K-Cl cotransport in vascular smooth muscle cells remains to be clarified. Recent studies of Na-K-Cl cotransport in vascular endothelial cells provide evidence that the cotransporter is important for regulation of endothelial cell volume and suggest that this Na cotransport system may be vitally important for normal function of the vasculature.

Original languageEnglish (US)
Pages (from-to)138-146
Number of pages9
JournalBlood Vessels
Volume28
Issue number1-3
StatePublished - 1991
Externally publishedYes

Fingerprint

Vascular Smooth Muscle
Smooth Muscle Myocytes
Sodium
Endothelial Cells
Inbred SHR Rats
Cell Size
Blood Vessels
Cell Membrane

Keywords

  • cell volume regulation
  • intracellular [Ca] regulation
  • intracellular pH regulation
  • Na-K-Cl cotransport
  • Na/Ca exchange
  • Na/H exchange
  • vascular endothelial cell
  • vascular smooth muscle cell

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Sodium cotransport in vascular smooth muscle cells. / O'Donnell, Martha E; Owen, N. E.

In: Blood Vessels, Vol. 28, No. 1-3, 1991, p. 138-146.

Research output: Contribution to journalArticle

O'Donnell, ME & Owen, NE 1991, 'Sodium cotransport in vascular smooth muscle cells', Blood Vessels, vol. 28, no. 1-3, pp. 138-146.
O'Donnell, Martha E ; Owen, N. E. / Sodium cotransport in vascular smooth muscle cells. In: Blood Vessels. 1991 ; Vol. 28, No. 1-3. pp. 138-146.
@article{b997c1c1270d4d0a96a1ba527796976d,
title = "Sodium cotransport in vascular smooth muscle cells",
abstract = "Vascular smooth muscle cells possess a number of Na cotransport systems. Three of these cotransport systems, Na/Ca exchange, Na/H exchange and Na-K-Cl cotransport, have been the subject of an increasing number of investigations to determine the respective roles of these transporters in vascular smooth muscle cell function. Evidence has been obtained that the Na/Ca exchange system participates in regulation of intracellular Ca in vascular smooth muscle cells. The Na/H exchange system appears to function in concert with a Cl/HCO3 exchange system to regulate intracellular pH. The Na-K-Cl cotransport system is a major contributor to K flux across the plasma membrane of vascular smooth muscle cells and is regulated by a number of vasoactive agents, suggesting that this Na cotransport system is also an important component of vascular smooth muscle cell function. Cultured vascular smooth muscle cells derived from spontaneously hypertensive rats have been found to exhibit reduced Na-K-Cl cotransport activity compared to smooth muscle cells from normotensive controls. Thus, alteration of vascular smooth muscle Na-K-Cl cotransport activity may be related to changes in vascular tone. However, the precise function of Na-K-Cl cotransport in vascular smooth muscle cells remains to be clarified. Recent studies of Na-K-Cl cotransport in vascular endothelial cells provide evidence that the cotransporter is important for regulation of endothelial cell volume and suggest that this Na cotransport system may be vitally important for normal function of the vasculature.",
keywords = "cell volume regulation, intracellular [Ca] regulation, intracellular pH regulation, Na-K-Cl cotransport, Na/Ca exchange, Na/H exchange, vascular endothelial cell, vascular smooth muscle cell",
author = "O'Donnell, {Martha E} and Owen, {N. E.}",
year = "1991",
language = "English (US)",
volume = "28",
pages = "138--146",
journal = "Journal of Vascular Research",
issn = "1018-1172",
publisher = "S. Karger AG",
number = "1-3",

}

TY - JOUR

T1 - Sodium cotransport in vascular smooth muscle cells

AU - O'Donnell, Martha E

AU - Owen, N. E.

PY - 1991

Y1 - 1991

N2 - Vascular smooth muscle cells possess a number of Na cotransport systems. Three of these cotransport systems, Na/Ca exchange, Na/H exchange and Na-K-Cl cotransport, have been the subject of an increasing number of investigations to determine the respective roles of these transporters in vascular smooth muscle cell function. Evidence has been obtained that the Na/Ca exchange system participates in regulation of intracellular Ca in vascular smooth muscle cells. The Na/H exchange system appears to function in concert with a Cl/HCO3 exchange system to regulate intracellular pH. The Na-K-Cl cotransport system is a major contributor to K flux across the plasma membrane of vascular smooth muscle cells and is regulated by a number of vasoactive agents, suggesting that this Na cotransport system is also an important component of vascular smooth muscle cell function. Cultured vascular smooth muscle cells derived from spontaneously hypertensive rats have been found to exhibit reduced Na-K-Cl cotransport activity compared to smooth muscle cells from normotensive controls. Thus, alteration of vascular smooth muscle Na-K-Cl cotransport activity may be related to changes in vascular tone. However, the precise function of Na-K-Cl cotransport in vascular smooth muscle cells remains to be clarified. Recent studies of Na-K-Cl cotransport in vascular endothelial cells provide evidence that the cotransporter is important for regulation of endothelial cell volume and suggest that this Na cotransport system may be vitally important for normal function of the vasculature.

AB - Vascular smooth muscle cells possess a number of Na cotransport systems. Three of these cotransport systems, Na/Ca exchange, Na/H exchange and Na-K-Cl cotransport, have been the subject of an increasing number of investigations to determine the respective roles of these transporters in vascular smooth muscle cell function. Evidence has been obtained that the Na/Ca exchange system participates in regulation of intracellular Ca in vascular smooth muscle cells. The Na/H exchange system appears to function in concert with a Cl/HCO3 exchange system to regulate intracellular pH. The Na-K-Cl cotransport system is a major contributor to K flux across the plasma membrane of vascular smooth muscle cells and is regulated by a number of vasoactive agents, suggesting that this Na cotransport system is also an important component of vascular smooth muscle cell function. Cultured vascular smooth muscle cells derived from spontaneously hypertensive rats have been found to exhibit reduced Na-K-Cl cotransport activity compared to smooth muscle cells from normotensive controls. Thus, alteration of vascular smooth muscle Na-K-Cl cotransport activity may be related to changes in vascular tone. However, the precise function of Na-K-Cl cotransport in vascular smooth muscle cells remains to be clarified. Recent studies of Na-K-Cl cotransport in vascular endothelial cells provide evidence that the cotransporter is important for regulation of endothelial cell volume and suggest that this Na cotransport system may be vitally important for normal function of the vasculature.

KW - cell volume regulation

KW - intracellular [Ca] regulation

KW - intracellular pH regulation

KW - Na-K-Cl cotransport

KW - Na/Ca exchange

KW - Na/H exchange

KW - vascular endothelial cell

KW - vascular smooth muscle cell

UR - http://www.scopus.com/inward/record.url?scp=0026090090&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026090090&partnerID=8YFLogxK

M3 - Article

C2 - 1848123

AN - SCOPUS:0026090090

VL - 28

SP - 138

EP - 146

JO - Journal of Vascular Research

JF - Journal of Vascular Research

SN - 1018-1172

IS - 1-3

ER -