Socioeconomic status and lung cancer

Unraveling the contribution of genetic admixture

Melinda C. Aldrich, Steve Selvin, Margaret R. Wrensch, Jennette D. Sison, Helen M. Hansen, Charles P. Quesenberry, Michael F Seldin, Lisa F. Barcellos, Patricia A. Buffler, John K. Wiencke

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Objectives. We examined the relationship between genetic ancestry, socioeconomic status (SES), and lung cancer among African Americans and Latinos. Methods. We evaluated SES and genetic ancestry in a Northern California lung cancer case-control study (1998-2003) of African Americans and Latinos. Lung cancer case and control participants were frequency matched on age, gender, and race/ethnicity. We assessed case-control differences in individual admixture proportions using the 2-sample t test and analysis of covariance. Logistic regression models examined associations among genetic ancestry, socioeconomic characteristics, and lung cancer. Results. Decreased Amerindian ancestry was associated with higher education among Latino control participants and greater African ancestry was associated with decreased education among African lung cancer case participants. Education was associated with lung cancer among both Latinos and African Americans, independent of smoking, ancestry, age, and gender. Genetic ancestry was not associated with lung cancer among African Americans. Conclusions. Findings suggest that socioeconomic factors may have a greater impact than genetic ancestry on lung cancer among African Americans. The genetic heterogeneity and recent dynamic migration and acculturation of Latinos complicate recruitment; thus, epidemiological analyses and findings should be interpreted cautiously.

Original languageEnglish (US)
JournalAmerican Journal of Public Health
Volume103
Issue number10
DOIs
StatePublished - Oct 2013

Fingerprint

Social Class
Lung Neoplasms
Hispanic Americans
African Americans
Education
Logistic Models
Acculturation
Genetic Heterogeneity
Individuality
Case-Control Studies
Smoking

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Cite this

Aldrich, M. C., Selvin, S., Wrensch, M. R., Sison, J. D., Hansen, H. M., Quesenberry, C. P., ... Wiencke, J. K. (2013). Socioeconomic status and lung cancer: Unraveling the contribution of genetic admixture. American Journal of Public Health, 103(10). https://doi.org/10.2105/AJPH.2013.301370

Socioeconomic status and lung cancer : Unraveling the contribution of genetic admixture. / Aldrich, Melinda C.; Selvin, Steve; Wrensch, Margaret R.; Sison, Jennette D.; Hansen, Helen M.; Quesenberry, Charles P.; Seldin, Michael F; Barcellos, Lisa F.; Buffler, Patricia A.; Wiencke, John K.

In: American Journal of Public Health, Vol. 103, No. 10, 10.2013.

Research output: Contribution to journalArticle

Aldrich, MC, Selvin, S, Wrensch, MR, Sison, JD, Hansen, HM, Quesenberry, CP, Seldin, MF, Barcellos, LF, Buffler, PA & Wiencke, JK 2013, 'Socioeconomic status and lung cancer: Unraveling the contribution of genetic admixture', American Journal of Public Health, vol. 103, no. 10. https://doi.org/10.2105/AJPH.2013.301370
Aldrich, Melinda C. ; Selvin, Steve ; Wrensch, Margaret R. ; Sison, Jennette D. ; Hansen, Helen M. ; Quesenberry, Charles P. ; Seldin, Michael F ; Barcellos, Lisa F. ; Buffler, Patricia A. ; Wiencke, John K. / Socioeconomic status and lung cancer : Unraveling the contribution of genetic admixture. In: American Journal of Public Health. 2013 ; Vol. 103, No. 10.
@article{34fcb11f61d84dfc9737026d77cae901,
title = "Socioeconomic status and lung cancer: Unraveling the contribution of genetic admixture",
abstract = "Objectives. We examined the relationship between genetic ancestry, socioeconomic status (SES), and lung cancer among African Americans and Latinos. Methods. We evaluated SES and genetic ancestry in a Northern California lung cancer case-control study (1998-2003) of African Americans and Latinos. Lung cancer case and control participants were frequency matched on age, gender, and race/ethnicity. We assessed case-control differences in individual admixture proportions using the 2-sample t test and analysis of covariance. Logistic regression models examined associations among genetic ancestry, socioeconomic characteristics, and lung cancer. Results. Decreased Amerindian ancestry was associated with higher education among Latino control participants and greater African ancestry was associated with decreased education among African lung cancer case participants. Education was associated with lung cancer among both Latinos and African Americans, independent of smoking, ancestry, age, and gender. Genetic ancestry was not associated with lung cancer among African Americans. Conclusions. Findings suggest that socioeconomic factors may have a greater impact than genetic ancestry on lung cancer among African Americans. The genetic heterogeneity and recent dynamic migration and acculturation of Latinos complicate recruitment; thus, epidemiological analyses and findings should be interpreted cautiously.",
author = "Aldrich, {Melinda C.} and Steve Selvin and Wrensch, {Margaret R.} and Sison, {Jennette D.} and Hansen, {Helen M.} and Quesenberry, {Charles P.} and Seldin, {Michael F} and Barcellos, {Lisa F.} and Buffler, {Patricia A.} and Wiencke, {John K.}",
year = "2013",
month = "10",
doi = "10.2105/AJPH.2013.301370",
language = "English (US)",
volume = "103",
journal = "American Journal of Public Health",
issn = "0090-0036",
publisher = "American Public Health Association Inc.",
number = "10",

}

TY - JOUR

T1 - Socioeconomic status and lung cancer

T2 - Unraveling the contribution of genetic admixture

AU - Aldrich, Melinda C.

AU - Selvin, Steve

AU - Wrensch, Margaret R.

AU - Sison, Jennette D.

AU - Hansen, Helen M.

AU - Quesenberry, Charles P.

AU - Seldin, Michael F

AU - Barcellos, Lisa F.

AU - Buffler, Patricia A.

AU - Wiencke, John K.

PY - 2013/10

Y1 - 2013/10

N2 - Objectives. We examined the relationship between genetic ancestry, socioeconomic status (SES), and lung cancer among African Americans and Latinos. Methods. We evaluated SES and genetic ancestry in a Northern California lung cancer case-control study (1998-2003) of African Americans and Latinos. Lung cancer case and control participants were frequency matched on age, gender, and race/ethnicity. We assessed case-control differences in individual admixture proportions using the 2-sample t test and analysis of covariance. Logistic regression models examined associations among genetic ancestry, socioeconomic characteristics, and lung cancer. Results. Decreased Amerindian ancestry was associated with higher education among Latino control participants and greater African ancestry was associated with decreased education among African lung cancer case participants. Education was associated with lung cancer among both Latinos and African Americans, independent of smoking, ancestry, age, and gender. Genetic ancestry was not associated with lung cancer among African Americans. Conclusions. Findings suggest that socioeconomic factors may have a greater impact than genetic ancestry on lung cancer among African Americans. The genetic heterogeneity and recent dynamic migration and acculturation of Latinos complicate recruitment; thus, epidemiological analyses and findings should be interpreted cautiously.

AB - Objectives. We examined the relationship between genetic ancestry, socioeconomic status (SES), and lung cancer among African Americans and Latinos. Methods. We evaluated SES and genetic ancestry in a Northern California lung cancer case-control study (1998-2003) of African Americans and Latinos. Lung cancer case and control participants were frequency matched on age, gender, and race/ethnicity. We assessed case-control differences in individual admixture proportions using the 2-sample t test and analysis of covariance. Logistic regression models examined associations among genetic ancestry, socioeconomic characteristics, and lung cancer. Results. Decreased Amerindian ancestry was associated with higher education among Latino control participants and greater African ancestry was associated with decreased education among African lung cancer case participants. Education was associated with lung cancer among both Latinos and African Americans, independent of smoking, ancestry, age, and gender. Genetic ancestry was not associated with lung cancer among African Americans. Conclusions. Findings suggest that socioeconomic factors may have a greater impact than genetic ancestry on lung cancer among African Americans. The genetic heterogeneity and recent dynamic migration and acculturation of Latinos complicate recruitment; thus, epidemiological analyses and findings should be interpreted cautiously.

UR - http://www.scopus.com/inward/record.url?scp=84884134051&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84884134051&partnerID=8YFLogxK

U2 - 10.2105/AJPH.2013.301370

DO - 10.2105/AJPH.2013.301370

M3 - Article

VL - 103

JO - American Journal of Public Health

JF - American Journal of Public Health

SN - 0090-0036

IS - 10

ER -