Social transmission of food preference in mice: Methodology and application to galanin-overexpressing transgenic mice

Craige C. Wrenn, Ashley P. Harris, Maria C. Saavedra, Jacqueline Crawley

Research output: Contribution to journalArticle

88 Scopus citations

Abstract

Social transmission of food preference (STFP) is a test of olfactory memory that can be used in mice. Confounds in STFP that can lead to misinterpretation of an STFP deficit as a memory impairment include changes in social interaction and olfaction. The issue of changes in social interaction was addressed by evaluating an observer-centric and a demonstrator-centric method for scoring the interaction phase of STFP in mice. The demonstrator-centric method was applied to a line of STFP-impaired, galaninoverexpressing transgenic (GAL-tg). GAL-tg mice were impaired in STFP without deficits in social interaction. In tests of olfactory ability, GAL-tg mice were unimpaired on buried-food and habituationdishabituation tasks. The current studies describe an expanded method for using STFP in mice and confirm a deficit in olfactory memory in GAL-tg mice.

Original languageEnglish (US)
Pages (from-to)21-31
Number of pages11
JournalBehavioral Neuroscience
Volume117
Issue number1
DOIs
StatePublished - Feb 2003
Externally publishedYes

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ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Clinical Psychology

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