Social transmission of food preference in mice: Methodology and application to galanin-overexpressing transgenic mice

Craige C. Wrenn; Ashley P. Harris; Maria C. Saavedra; Jacqueline Crawley

doi:10.1037/0735-7044.117.1.21

Social transmission of food preference in mice: Methodology and application to galanin-overexpressing transgenic mice

Craige C. Wrenn, Ashley P. Harris, Maria C. Saavedra, Jacqueline Crawley

Research output: Contribution to journal › Article › peer-review

90 Scopus citations

Abstract

Social transmission of food preference (STFP) is a test of olfactory memory that can be used in mice. Confounds in STFP that can lead to misinterpretation of an STFP deficit as a memory impairment include changes in social interaction and olfaction. The issue of changes in social interaction was addressed by evaluating an observer-centric and a demonstrator-centric method for scoring the interaction phase of STFP in mice. The demonstrator-centric method was applied to a line of STFP-impaired, galaninoverexpressing transgenic (GAL-tg). GAL-tg mice were impaired in STFP without deficits in social interaction. In tests of olfactory ability, GAL-tg mice were unimpaired on buried-food and habituationdishabituation tasks. The current studies describe an expanded method for using STFP in mice and confirm a deficit in olfactory memory in GAL-tg mice.

Original language	English (US)
Pages (from-to)	21-31
Number of pages	11
Journal	Behavioral Neuroscience
Volume	117
Issue number	1
DOIs	https://doi.org/10.1037/0735-7044.117.1.21
State	Published - Feb 2003
Externally published	Yes

ASJC Scopus subject areas

Behavioral Neuroscience
Clinical Psychology

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abstract = "Social transmission of food preference (STFP) is a test of olfactory memory that can be used in mice. Confounds in STFP that can lead to misinterpretation of an STFP deficit as a memory impairment include changes in social interaction and olfaction. The issue of changes in social interaction was addressed by evaluating an observer-centric and a demonstrator-centric method for scoring the interaction phase of STFP in mice. The demonstrator-centric method was applied to a line of STFP-impaired, galaninoverexpressing transgenic (GAL-tg). GAL-tg mice were impaired in STFP without deficits in social interaction. In tests of olfactory ability, GAL-tg mice were unimpaired on buried-food and habituationdishabituation tasks. The current studies describe an expanded method for using STFP in mice and confirm a deficit in olfactory memory in GAL-tg mice.",

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Social transmission of food preference in mice: Methodology and application to galanin-overexpressing transgenic mice

Abstract

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