Social networks, social support and burden in relationships, and mortality after breast cancer diagnosis

Candyce H. Kroenke, Yvonne Michael, Hilary Tindle, Elizabeth Gage, Rowan Chlebowski, Lorena Garcia, Catherine Messina, Joann E. Manson, Bette J. Caan

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Though larger social networks are associated with reduced breast cancer mortality, there is a need to clarify how both social support and social burden influence this association. We included 4,530 women from the Women's Health Initiative who were diagnosed with breast cancer between 1993 and 2009, and provided data on social networks (spouse or intimate partner, religious ties, club ties, and number of first-degree relatives) before diagnosis. Of those, 354 died during follow-up, with 190 from breast cancer. We used Cox proportional hazards regression to evaluate associations of social network members with risk of post-diagnosis mortality, further evaluating associations by social support and social burden (caregiving, social strain). In multivariate-adjusted analyses, among women with high but not low social support, being married was related to lower all-cause mortality. By contrast, among women with high but not low social burden, those with a higher number of first-degree relatives, including siblings, parents, and children, had higher all-cause and breast cancer mortality (among caregivers: 0-3 relatives (ref), 4-5 relatives, HR = 1.47 (95% CI: 0.62-3.52), 6-9 relatives, HR = 2.08 (95% CI: 0.89-4.86), 10+ relatives, HR = 3.55 (95% CI: 1.35-9.33), P-continuous = 0.02, P-interaction = 0.008). The association by social strain was similar though it was not modified by level of social support. Other social network members were unrelated to mortality. Social relationships may have both adverse and beneficial influences on breast cancer survival. Clarifying these depends on understanding the context of women's relationships.

Original languageEnglish (US)
Pages (from-to)375-385
Number of pages11
JournalBreast Cancer Research and Treatment
Volume133
Issue number1
DOIs
StatePublished - May 2012

Fingerprint

Social Support
Breast Neoplasms
Mortality
Women's Health
Spouses
Caregivers
Siblings
Multivariate Analysis
Parents
Survival

Keywords

  • Breast cancer
  • Caregiving
  • Mortality
  • Social burden
  • Social networks
  • Social relationships
  • Social support
  • Stress
  • Women

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Social networks, social support and burden in relationships, and mortality after breast cancer diagnosis. / Kroenke, Candyce H.; Michael, Yvonne; Tindle, Hilary; Gage, Elizabeth; Chlebowski, Rowan; Garcia, Lorena; Messina, Catherine; Manson, Joann E.; Caan, Bette J.

In: Breast Cancer Research and Treatment, Vol. 133, No. 1, 05.2012, p. 375-385.

Research output: Contribution to journalArticle

Kroenke, CH, Michael, Y, Tindle, H, Gage, E, Chlebowski, R, Garcia, L, Messina, C, Manson, JE & Caan, BJ 2012, 'Social networks, social support and burden in relationships, and mortality after breast cancer diagnosis', Breast Cancer Research and Treatment, vol. 133, no. 1, pp. 375-385. https://doi.org/10.1007/s10549-012-1962-3
Kroenke, Candyce H. ; Michael, Yvonne ; Tindle, Hilary ; Gage, Elizabeth ; Chlebowski, Rowan ; Garcia, Lorena ; Messina, Catherine ; Manson, Joann E. ; Caan, Bette J. / Social networks, social support and burden in relationships, and mortality after breast cancer diagnosis. In: Breast Cancer Research and Treatment. 2012 ; Vol. 133, No. 1. pp. 375-385.
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