TY - JOUR
T1 - Social interaction and sensorimotor gating abnormalities in mice lacking Dvl1
AU - Lijam, Nardos
AU - Paylor, Richard
AU - McDonald, Michael P.
AU - Crawley, Jacqueline
AU - Deng, Chu Xia
AU - Herrup, Karl
AU - Stevens, Karen E.
AU - Maccaferri, Gianmaria
AU - McBain, Chris J.
AU - Sussman, Daniel J.
AU - Wynshaw-Boris, Anthony
PY - 1997
Y1 - 1997
N2 - Mice completely deficient for Dvl1, one of three mouse homologs of the Drosophila segment polarity gene Dishevelled, were created by gene targeting. Dvl1-deficient mice are viable, fertile, and structurally normal. Surprisingly, these mice exhibited reduced social interaction, including differences in whisker trimming, deficits in nest-building, less huddling contact during home cage sleeping, and subordinate responses in a social dominance test. Sensorimotor gating was abnormal, as measured by deficits in prepulse inhibition of acoustic and tactile startle. Thus, Dvl1 mutants may provide a model for aspects of several human psychiatric disorders. These results are consistent with an interpretation that common genetic mechanisms underlie abnormal social behavior and sensorimotor gating deficits and implicate Dvl1 in processes underlying complex behaviors.
AB - Mice completely deficient for Dvl1, one of three mouse homologs of the Drosophila segment polarity gene Dishevelled, were created by gene targeting. Dvl1-deficient mice are viable, fertile, and structurally normal. Surprisingly, these mice exhibited reduced social interaction, including differences in whisker trimming, deficits in nest-building, less huddling contact during home cage sleeping, and subordinate responses in a social dominance test. Sensorimotor gating was abnormal, as measured by deficits in prepulse inhibition of acoustic and tactile startle. Thus, Dvl1 mutants may provide a model for aspects of several human psychiatric disorders. These results are consistent with an interpretation that common genetic mechanisms underlie abnormal social behavior and sensorimotor gating deficits and implicate Dvl1 in processes underlying complex behaviors.
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U2 - 10.1016/S0092-8674(00)80354-2
DO - 10.1016/S0092-8674(00)80354-2
M3 - Article
C2 - 9298901
AN - SCOPUS:0030866899
VL - 90
SP - 895
EP - 905
JO - Cell
JF - Cell
SN - 0092-8674
IS - 5
ER -