Social interaction and sensorimotor gating abnormalities in mice lacking Dvl1

Nardos Lijam, Richard Paylor, Michael P. McDonald, Jacqueline Crawley, Chu Xia Deng, Karl Herrup, Karen E. Stevens, Gianmaria Maccaferri, Chris J. McBain, Daniel J. Sussman, Anthony Wynshaw-Boris

Research output: Contribution to journalArticle

381 Scopus citations

Abstract

Mice completely deficient for Dvl1, one of three mouse homologs of the Drosophila segment polarity gene Dishevelled, were created by gene targeting. Dvl1-deficient mice are viable, fertile, and structurally normal. Surprisingly, these mice exhibited reduced social interaction, including differences in whisker trimming, deficits in nest-building, less huddling contact during home cage sleeping, and subordinate responses in a social dominance test. Sensorimotor gating was abnormal, as measured by deficits in prepulse inhibition of acoustic and tactile startle. Thus, Dvl1 mutants may provide a model for aspects of several human psychiatric disorders. These results are consistent with an interpretation that common genetic mechanisms underlie abnormal social behavior and sensorimotor gating deficits and implicate Dvl1 in processes underlying complex behaviors.

Original languageEnglish (US)
Pages (from-to)895-905
Number of pages11
JournalCell
Volume90
Issue number5
DOIs
StatePublished - 1997
Externally publishedYes

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

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    Lijam, N., Paylor, R., McDonald, M. P., Crawley, J., Deng, C. X., Herrup, K., Stevens, K. E., Maccaferri, G., McBain, C. J., Sussman, D. J., & Wynshaw-Boris, A. (1997). Social interaction and sensorimotor gating abnormalities in mice lacking Dvl1. Cell, 90(5), 895-905. https://doi.org/10.1016/S0092-8674(00)80354-2