So little source, so much sink: Requirements for afterdepolarizations to propagate in tissue

Yuanfang Xie, Daisuke Sato, Alan Garfinkel, Zhilin Qu, James N. Weiss

Research output: Contribution to journalArticlepeer-review

216 Scopus citations


How early (EADs) and delayed after depolarizations (DADs) overcome electrotonic source-sink mismatches in tissue to trigger premature ventricular complexes remains incompletely understood. To study this question, we used a rabbit ventricular action potential model to simulate tissues in which a central area of contiguous myocytes susceptible to EADs or DADs was surrounded by unsusceptible tissue. In 1D tissue with normal longitudinal conduction velocity (0.55 m/s), the numbers of contiguous susceptible myocytes required for an EAD and a barely suprathreshold DAD to trigger a propagating action potential were 70 and 80, respectively. In 2D tissue, these numbers increased to 6940 and 7854, and in 3D tissue to 696,910 and 817,280. These numbers were significantly decreased by reduced gap junction conductance, simulated fibrosis, reduced repolarization reserve and heart failure electrical remodeling. In conclusion, the source-sink mismatch in well-coupled cardiac tissue powerfully protects the heart from arrhythmias due to sporadic afterdepolarizations. Structural and electrophysiological remodeling decrease these numbers significantly but still require synchronization mechanisms for EADs and DADs to overcome the robust protective effects of source-sink mismatch.

Original languageEnglish (US)
Pages (from-to)1408-1415
Number of pages8
JournalBiophysical Journal
Issue number5
StatePublished - Sep 8 2010

ASJC Scopus subject areas

  • Biophysics


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