Snord116-dependent diurnal rhythm of DNA methylation in mouse cortex

Rochelle L. Coulson, Dag H. Yasui, Keith W. Dunaway, Benjamin I. Laufer, Annie Vogel Ciernia, Yihui Zhu, Charles E. Mordaunt, Theresa S. Totah, Janine M LaSalle

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Rhythmic oscillations of physiological processes depend on integrating the circadian clock and diurnal environment. DNA methylation is epigenetically responsive to daily rhythms, as a subset of CpG dinucleotides in brain exhibit diurnal rhythmic methylation. Here, we show a major genetic effect on rhythmic methylation in a mouse Snord116 deletion model of the imprinted disorder Prader-Willi syndrome (PWS). More than 23,000 diurnally rhythmic CpGs are identified in wild-type cortex, with nearly all lost or phase-shifted in PWS. Circadian dysregulation of a second imprinted Snord cluster at the Temple/Kagami-Ogata syndrome locus is observed at the level of methylation, transcription, and chromatin, providing mechanistic evidence of cross-talk. Genes identified by diurnal epigenetic changes in PWS mice overlapped rhythmic and PWS-specific genes in human brain and are enriched for PWS-relevant phenotypes and pathways. These results support the proposed evolutionary relationship between imprinting and sleep, and suggest possible chronotherapy in the treatment of PWS and related disorders.

Original languageEnglish (US)
Article number1616
JournalNature Communications
Volume9
Issue number1
DOIs
StatePublished - Dec 1 2018

Fingerprint

circadian rhythms
Prader-Willi Syndrome
methylation
Methylation
cortexes
DNA Methylation
Circadian Rhythm
mice
deoxyribonucleic acid
Brain
Genes
Transcription
Chromatin
Clocks
Chronobiology Disorders
genes
brain
Chronotherapy
Physiological Phenomena
disorders

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

Cite this

Coulson, R. L., Yasui, D. H., Dunaway, K. W., Laufer, B. I., Vogel Ciernia, A., Zhu, Y., ... LaSalle, J. M. (2018). Snord116-dependent diurnal rhythm of DNA methylation in mouse cortex. Nature Communications, 9(1), [1616]. https://doi.org/10.1038/s41467-018-03676-0

Snord116-dependent diurnal rhythm of DNA methylation in mouse cortex. / Coulson, Rochelle L.; Yasui, Dag H.; Dunaway, Keith W.; Laufer, Benjamin I.; Vogel Ciernia, Annie; Zhu, Yihui; Mordaunt, Charles E.; Totah, Theresa S.; LaSalle, Janine M.

In: Nature Communications, Vol. 9, No. 1, 1616, 01.12.2018.

Research output: Contribution to journalArticle

Coulson, RL, Yasui, DH, Dunaway, KW, Laufer, BI, Vogel Ciernia, A, Zhu, Y, Mordaunt, CE, Totah, TS & LaSalle, JM 2018, 'Snord116-dependent diurnal rhythm of DNA methylation in mouse cortex', Nature Communications, vol. 9, no. 1, 1616. https://doi.org/10.1038/s41467-018-03676-0
Coulson RL, Yasui DH, Dunaway KW, Laufer BI, Vogel Ciernia A, Zhu Y et al. Snord116-dependent diurnal rhythm of DNA methylation in mouse cortex. Nature Communications. 2018 Dec 1;9(1). 1616. https://doi.org/10.1038/s41467-018-03676-0
Coulson, Rochelle L. ; Yasui, Dag H. ; Dunaway, Keith W. ; Laufer, Benjamin I. ; Vogel Ciernia, Annie ; Zhu, Yihui ; Mordaunt, Charles E. ; Totah, Theresa S. ; LaSalle, Janine M. / Snord116-dependent diurnal rhythm of DNA methylation in mouse cortex. In: Nature Communications. 2018 ; Vol. 9, No. 1.
@article{53059fb53b424d5fb07cca7a7f6677ed,
title = "Snord116-dependent diurnal rhythm of DNA methylation in mouse cortex",
abstract = "Rhythmic oscillations of physiological processes depend on integrating the circadian clock and diurnal environment. DNA methylation is epigenetically responsive to daily rhythms, as a subset of CpG dinucleotides in brain exhibit diurnal rhythmic methylation. Here, we show a major genetic effect on rhythmic methylation in a mouse Snord116 deletion model of the imprinted disorder Prader-Willi syndrome (PWS). More than 23,000 diurnally rhythmic CpGs are identified in wild-type cortex, with nearly all lost or phase-shifted in PWS. Circadian dysregulation of a second imprinted Snord cluster at the Temple/Kagami-Ogata syndrome locus is observed at the level of methylation, transcription, and chromatin, providing mechanistic evidence of cross-talk. Genes identified by diurnal epigenetic changes in PWS mice overlapped rhythmic and PWS-specific genes in human brain and are enriched for PWS-relevant phenotypes and pathways. These results support the proposed evolutionary relationship between imprinting and sleep, and suggest possible chronotherapy in the treatment of PWS and related disorders.",
author = "Coulson, {Rochelle L.} and Yasui, {Dag H.} and Dunaway, {Keith W.} and Laufer, {Benjamin I.} and {Vogel Ciernia}, Annie and Yihui Zhu and Mordaunt, {Charles E.} and Totah, {Theresa S.} and LaSalle, {Janine M}",
year = "2018",
month = "12",
day = "1",
doi = "10.1038/s41467-018-03676-0",
language = "English (US)",
volume = "9",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Nature Publishing Group",
number = "1",

}

TY - JOUR

T1 - Snord116-dependent diurnal rhythm of DNA methylation in mouse cortex

AU - Coulson, Rochelle L.

AU - Yasui, Dag H.

AU - Dunaway, Keith W.

AU - Laufer, Benjamin I.

AU - Vogel Ciernia, Annie

AU - Zhu, Yihui

AU - Mordaunt, Charles E.

AU - Totah, Theresa S.

AU - LaSalle, Janine M

PY - 2018/12/1

Y1 - 2018/12/1

N2 - Rhythmic oscillations of physiological processes depend on integrating the circadian clock and diurnal environment. DNA methylation is epigenetically responsive to daily rhythms, as a subset of CpG dinucleotides in brain exhibit diurnal rhythmic methylation. Here, we show a major genetic effect on rhythmic methylation in a mouse Snord116 deletion model of the imprinted disorder Prader-Willi syndrome (PWS). More than 23,000 diurnally rhythmic CpGs are identified in wild-type cortex, with nearly all lost or phase-shifted in PWS. Circadian dysregulation of a second imprinted Snord cluster at the Temple/Kagami-Ogata syndrome locus is observed at the level of methylation, transcription, and chromatin, providing mechanistic evidence of cross-talk. Genes identified by diurnal epigenetic changes in PWS mice overlapped rhythmic and PWS-specific genes in human brain and are enriched for PWS-relevant phenotypes and pathways. These results support the proposed evolutionary relationship between imprinting and sleep, and suggest possible chronotherapy in the treatment of PWS and related disorders.

AB - Rhythmic oscillations of physiological processes depend on integrating the circadian clock and diurnal environment. DNA methylation is epigenetically responsive to daily rhythms, as a subset of CpG dinucleotides in brain exhibit diurnal rhythmic methylation. Here, we show a major genetic effect on rhythmic methylation in a mouse Snord116 deletion model of the imprinted disorder Prader-Willi syndrome (PWS). More than 23,000 diurnally rhythmic CpGs are identified in wild-type cortex, with nearly all lost or phase-shifted in PWS. Circadian dysregulation of a second imprinted Snord cluster at the Temple/Kagami-Ogata syndrome locus is observed at the level of methylation, transcription, and chromatin, providing mechanistic evidence of cross-talk. Genes identified by diurnal epigenetic changes in PWS mice overlapped rhythmic and PWS-specific genes in human brain and are enriched for PWS-relevant phenotypes and pathways. These results support the proposed evolutionary relationship between imprinting and sleep, and suggest possible chronotherapy in the treatment of PWS and related disorders.

UR - http://www.scopus.com/inward/record.url?scp=85045963040&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85045963040&partnerID=8YFLogxK

U2 - 10.1038/s41467-018-03676-0

DO - 10.1038/s41467-018-03676-0

M3 - Article

C2 - 29691382

AN - SCOPUS:85045963040

VL - 9

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

IS - 1

M1 - 1616

ER -