SMRTε, a corepressor variant, interacts with a restricted subset of nuclear receptors, including the retinoic acid receptors α and β

Brenda J. Mengeling, Michael L. Goodson, William Bourguet, Martin L. Privalsky

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

The SMRT and NCoR corepressors bind to, and mediate transcriptional repression by, many nuclear receptors. Both SMRT and NCoR are expressed by alternative mRNA splicing, generating a series of structurally and functionally distinct corepressor " variants" We report that a splice variant of SMRT, SMRTε, recognizes a restricted subset of nuclear receptors. Unlike the other corepressor variants characterized, SMRTε possesses only a single receptor interaction domain (RID) and exhibits an unusual specificity for a subset of nuclear receptors that includes the retinoic acid receptors (RARs). The ability of the single RID in SMRTε to efficiently interact with RARs appears to be enhanced by a recently recognized β-strand/β-strand interaction between corepressor and receptor. We suggest that alternative mRNA splicing of corepressors can restrict their function to specific nuclear receptor partnerships, and we propose that this may serve to customize the transcriptional repression properties of different cell types for different biological purposes.

Original languageEnglish (US)
Pages (from-to)306-316
Number of pages11
JournalMolecular and Cellular Endocrinology
Volume351
Issue number2
DOIs
StatePublished - Apr 4 2012

Keywords

  • β-Strand
  • Alternative-mRNA splicing
  • Corepressors
  • Nuclear receptors
  • Retinoic acid receptors
  • SMRT

ASJC Scopus subject areas

  • Endocrinology
  • Molecular Biology
  • Biochemistry

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