Smooth Muscle Autoantibodies

Luigi Muratori, Pietro Invernizzi

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Serum smooth muscle autoantibodies (SMA) react with different proteins (actin, tubulin, vimentin, desmin, cytokeratins) of the cytoskeletal components (microfilaments, microtubuli, intermediate filaments). Their detection can be the hallmark of autoimmune diseases such as autoimmune hepatitis (AIH) or celiac disease; however, they can also be observed in viral diseases such as chronic hepatitis C and infectious mononucleosis. When present at high titers (> 1:80), they are considered sensitive markers of AIH, being found in up to 80% of cases. Within the spectrum of SMA, antiactin antibodies are the most specific for the diagnosis of AIH, whereas no convincing evidence of their pathogenetic or prognostic value has been provided yet. SMA of the immunoglobulin (Ig)A class with antiactin specificity have been described in a large majority of celiac patients with severe mucosal damage. The classical immunomorphologic techniques remain the gold standards for SMA testing; in addition, the new immunochemical tests with purified antigens appear to be a promising complementary approach.

Original languageEnglish (US)
Title of host publicationAutoantibodies: Third Edition
PublisherElsevier B.V.
Pages491-495
Number of pages5
ISBN (Print)9780444563781
DOIs
StatePublished - Dec 2013
Externally publishedYes

Fingerprint

Autoantibodies
Autoimmune Hepatitis
Smooth Muscle
Autoimmune Diseases
Infectious Mononucleosis
Desmin
Intermediate Filaments
Immunoglobulin Isotypes
Celiac Disease
Vimentin
Chronic Hepatitis C
Virus Diseases
Tubulin
Keratins
Abdomen
Immunoglobulin A
Actins
Antigens
Antibodies
Serum

Keywords

  • Antiactin
  • Autoantibodies
  • Cytoskeleton
  • Diagnosis
  • Indirect immunofluorescence
  • Prognosis

ASJC Scopus subject areas

  • Immunology and Microbiology(all)

Cite this

Muratori, L., & Invernizzi, P. (2013). Smooth Muscle Autoantibodies. In Autoantibodies: Third Edition (pp. 491-495). Elsevier B.V.. https://doi.org/10.1016/B978-0-444-56378-1.00058-7

Smooth Muscle Autoantibodies. / Muratori, Luigi; Invernizzi, Pietro.

Autoantibodies: Third Edition. Elsevier B.V., 2013. p. 491-495.

Research output: Chapter in Book/Report/Conference proceedingChapter

Muratori, L & Invernizzi, P 2013, Smooth Muscle Autoantibodies. in Autoantibodies: Third Edition. Elsevier B.V., pp. 491-495. https://doi.org/10.1016/B978-0-444-56378-1.00058-7
Muratori L, Invernizzi P. Smooth Muscle Autoantibodies. In Autoantibodies: Third Edition. Elsevier B.V. 2013. p. 491-495 https://doi.org/10.1016/B978-0-444-56378-1.00058-7
Muratori, Luigi ; Invernizzi, Pietro. / Smooth Muscle Autoantibodies. Autoantibodies: Third Edition. Elsevier B.V., 2013. pp. 491-495
@inbook{eede510ddee94e3681a73a262f0afca4,
title = "Smooth Muscle Autoantibodies",
abstract = "Serum smooth muscle autoantibodies (SMA) react with different proteins (actin, tubulin, vimentin, desmin, cytokeratins) of the cytoskeletal components (microfilaments, microtubuli, intermediate filaments). Their detection can be the hallmark of autoimmune diseases such as autoimmune hepatitis (AIH) or celiac disease; however, they can also be observed in viral diseases such as chronic hepatitis C and infectious mononucleosis. When present at high titers (> 1:80), they are considered sensitive markers of AIH, being found in up to 80{\%} of cases. Within the spectrum of SMA, antiactin antibodies are the most specific for the diagnosis of AIH, whereas no convincing evidence of their pathogenetic or prognostic value has been provided yet. SMA of the immunoglobulin (Ig)A class with antiactin specificity have been described in a large majority of celiac patients with severe mucosal damage. The classical immunomorphologic techniques remain the gold standards for SMA testing; in addition, the new immunochemical tests with purified antigens appear to be a promising complementary approach.",
keywords = "Antiactin, Autoantibodies, Cytoskeleton, Diagnosis, Indirect immunofluorescence, Prognosis",
author = "Luigi Muratori and Pietro Invernizzi",
year = "2013",
month = "12",
doi = "10.1016/B978-0-444-56378-1.00058-7",
language = "English (US)",
isbn = "9780444563781",
pages = "491--495",
booktitle = "Autoantibodies: Third Edition",
publisher = "Elsevier B.V.",

}

TY - CHAP

T1 - Smooth Muscle Autoantibodies

AU - Muratori, Luigi

AU - Invernizzi, Pietro

PY - 2013/12

Y1 - 2013/12

N2 - Serum smooth muscle autoantibodies (SMA) react with different proteins (actin, tubulin, vimentin, desmin, cytokeratins) of the cytoskeletal components (microfilaments, microtubuli, intermediate filaments). Their detection can be the hallmark of autoimmune diseases such as autoimmune hepatitis (AIH) or celiac disease; however, they can also be observed in viral diseases such as chronic hepatitis C and infectious mononucleosis. When present at high titers (> 1:80), they are considered sensitive markers of AIH, being found in up to 80% of cases. Within the spectrum of SMA, antiactin antibodies are the most specific for the diagnosis of AIH, whereas no convincing evidence of their pathogenetic or prognostic value has been provided yet. SMA of the immunoglobulin (Ig)A class with antiactin specificity have been described in a large majority of celiac patients with severe mucosal damage. The classical immunomorphologic techniques remain the gold standards for SMA testing; in addition, the new immunochemical tests with purified antigens appear to be a promising complementary approach.

AB - Serum smooth muscle autoantibodies (SMA) react with different proteins (actin, tubulin, vimentin, desmin, cytokeratins) of the cytoskeletal components (microfilaments, microtubuli, intermediate filaments). Their detection can be the hallmark of autoimmune diseases such as autoimmune hepatitis (AIH) or celiac disease; however, they can also be observed in viral diseases such as chronic hepatitis C and infectious mononucleosis. When present at high titers (> 1:80), they are considered sensitive markers of AIH, being found in up to 80% of cases. Within the spectrum of SMA, antiactin antibodies are the most specific for the diagnosis of AIH, whereas no convincing evidence of their pathogenetic or prognostic value has been provided yet. SMA of the immunoglobulin (Ig)A class with antiactin specificity have been described in a large majority of celiac patients with severe mucosal damage. The classical immunomorphologic techniques remain the gold standards for SMA testing; in addition, the new immunochemical tests with purified antigens appear to be a promising complementary approach.

KW - Antiactin

KW - Autoantibodies

KW - Cytoskeleton

KW - Diagnosis

KW - Indirect immunofluorescence

KW - Prognosis

UR - http://www.scopus.com/inward/record.url?scp=84902061619&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84902061619&partnerID=8YFLogxK

U2 - 10.1016/B978-0-444-56378-1.00058-7

DO - 10.1016/B978-0-444-56378-1.00058-7

M3 - Chapter

AN - SCOPUS:84902061619

SN - 9780444563781

SP - 491

EP - 495

BT - Autoantibodies: Third Edition

PB - Elsevier B.V.

ER -