Smooth muscle antibodies

Carlo Selmi, Paolo Muratori, Mauro Podda, Francesco B. Bianchi

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Citations (Scopus)

Abstract

Serum smooth muscle autoantibodies (SMA) react with different proteins (actin, tubulin, vimentin, desmin, cytokeratins) of the cytoskeletal components (microfilaments, microtubuli, intermediate filaments). Their presence characterizes both autoimmune (type 1 autoimmune hepatitis, coeliac disease) and viral diseases (chronic hepatitis C, infectious mononucleosis). When detected at titers higher than 1:80, they are considered a sensitive marker for type I autoimmune hepatitis (AIH), being found in up to 80% of cases. Within the spectrum of SMA, antiactin antibodies are most specific for the diagnosis of type 1 AIH, but they lack evidence of pathogenetic or prognostic value. Antiactin SMA of the IgA class have been described in coeliac patients in association with more severe intestinal histology; it is still controversial whether they should be considered as a secondary epiphenomenon or have a pathogenetic relevance. At present, immunomorphological techniques are still the gold standard for SMA testing; recently, however, new immunochemical tests with purified antigens have been demonstrated to be reliable. The detection of SMA is based on indirect immunifluorescence (IIF) technique using conventional substrates, such as rodent stomach, liver and kidney, in particular, SMA reacts with the wall of small arteries present in all three tissues; analysis of the kidney reactivity is of relevance, as it allows to easily recognize three immunomorphological patterns described: SMA-V (vessels), SMA-G (glomeruli), and SMA-T (tubuli).

Original languageEnglish (US)
Title of host publicationAutoantibodies
PublisherElsevier Inc.
Pages487-491
Number of pages5
ISBN (Print)9780444527639
DOIs
StatePublished - 2007

Fingerprint

Autoantibodies
Smooth Muscle
Muscle
Antibodies
Autoimmune Hepatitis
Kidney
Infectious Mononucleosis
Histology
Desmin
Intermediate Filaments
Celiac Disease
Vimentin
Chronic Hepatitis C
Virus Diseases
Tubulin
Keratins
Liver
Abdomen
Immunoglobulin A
Actins

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Selmi, C., Muratori, P., Podda, M., & Bianchi, F. B. (2007). Smooth muscle antibodies. In Autoantibodies (pp. 487-491). Elsevier Inc.. https://doi.org/10.1016/B978-044452763-9/50065-2

Smooth muscle antibodies. / Selmi, Carlo; Muratori, Paolo; Podda, Mauro; Bianchi, Francesco B.

Autoantibodies. Elsevier Inc., 2007. p. 487-491.

Research output: Chapter in Book/Report/Conference proceedingChapter

Selmi, C, Muratori, P, Podda, M & Bianchi, FB 2007, Smooth muscle antibodies. in Autoantibodies. Elsevier Inc., pp. 487-491. https://doi.org/10.1016/B978-044452763-9/50065-2
Selmi C, Muratori P, Podda M, Bianchi FB. Smooth muscle antibodies. In Autoantibodies. Elsevier Inc. 2007. p. 487-491 https://doi.org/10.1016/B978-044452763-9/50065-2
Selmi, Carlo ; Muratori, Paolo ; Podda, Mauro ; Bianchi, Francesco B. / Smooth muscle antibodies. Autoantibodies. Elsevier Inc., 2007. pp. 487-491
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