Smoking influences the immunological architecture of the human larynx

Louisa E N Rees, Philip H. Jones, Omar Ayoub, Sinnappa Gunasekaran, Krishnan Rajkumar, Christopher R. Stokes, Karin Haverson, Mick Bailey, Martin A. Birchall

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Little is known about the effects of demographic and lifestyle factors on laryngeal mucosal immunology. Pinch biopsies of laryngeal mucosa were studied from 63 patients without laryngeal disease. Areas of positive staining for HLA-DR, HLA-DQ, HLA-DP, CD45, CD45RA, CD45RO, CD4, CD8, and CD79 were calculated. Patients were stratified according to gender and smoking status. Analysis of covariance showed current cigarette smokers had increased numbers of CD4+ T cells and there was an association between older age and greater CD4+ T cell numbers in both epithelium and lamina propria. Older age and female gender were associated with decreased lamina propria CD4+ CD45RO+ T cells and an increase in CD4+ CD45RO- T cells. T cell populations in the larynx may therefore be influenced by smoking, age and gender. We hypothesize that smoking induces changes in normal immunological function of the larynx, which may contribute to the etiology of inflammatory disease and cancer.

Original languageEnglish (US)
Pages (from-to)342-347
Number of pages6
JournalClinical Immunology
Volume118
Issue number2-3
DOIs
StatePublished - Feb 2006
Externally publishedYes

Fingerprint

Larynx
Smoking
T-Lymphocytes
Mucous Membrane
Laryngeal Diseases
Laryngeal Mucosa
HLA-DP Antigens
HLA-DQ Antigens
HLA-DR Antigens
Allergy and Immunology
Tobacco Products
Life Style
Epithelium
Cell Count
Demography
Staining and Labeling
Biopsy
Population
Neoplasms

Keywords

  • Mucosal immunity
  • Risk factors
  • Smoking
  • T cells

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Rees, L. E. N., Jones, P. H., Ayoub, O., Gunasekaran, S., Rajkumar, K., Stokes, C. R., ... Birchall, M. A. (2006). Smoking influences the immunological architecture of the human larynx. Clinical Immunology, 118(2-3), 342-347. https://doi.org/10.1016/j.clim.2005.10.015

Smoking influences the immunological architecture of the human larynx. / Rees, Louisa E N; Jones, Philip H.; Ayoub, Omar; Gunasekaran, Sinnappa; Rajkumar, Krishnan; Stokes, Christopher R.; Haverson, Karin; Bailey, Mick; Birchall, Martin A.

In: Clinical Immunology, Vol. 118, No. 2-3, 02.2006, p. 342-347.

Research output: Contribution to journalArticle

Rees, LEN, Jones, PH, Ayoub, O, Gunasekaran, S, Rajkumar, K, Stokes, CR, Haverson, K, Bailey, M & Birchall, MA 2006, 'Smoking influences the immunological architecture of the human larynx', Clinical Immunology, vol. 118, no. 2-3, pp. 342-347. https://doi.org/10.1016/j.clim.2005.10.015
Rees LEN, Jones PH, Ayoub O, Gunasekaran S, Rajkumar K, Stokes CR et al. Smoking influences the immunological architecture of the human larynx. Clinical Immunology. 2006 Feb;118(2-3):342-347. https://doi.org/10.1016/j.clim.2005.10.015
Rees, Louisa E N ; Jones, Philip H. ; Ayoub, Omar ; Gunasekaran, Sinnappa ; Rajkumar, Krishnan ; Stokes, Christopher R. ; Haverson, Karin ; Bailey, Mick ; Birchall, Martin A. / Smoking influences the immunological architecture of the human larynx. In: Clinical Immunology. 2006 ; Vol. 118, No. 2-3. pp. 342-347.
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