Smoking and survival after breast cancer diagnosis

Michelle D. Holmes, Susan Murin, Wendy Y. Chen, Candyce H. Kroenke, Donna Spiegelman, Graham A. Colditz

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

We examined whether a history of smoking is associated with an increased risk of death from any cause or from breast cancer, among women diagnosed with breast cancer. This was a prospective observational study among 5,056 women from the Nurses' Health Study with Stages I-III invasive breast cancer diagnosed between 1978 and 2002 and for whom we had information on smoking, and who were followed until January 2002 or death, whichever came first. Subjects were classified as current, former or never smokers based upon smoking status at the biennial questionnaire immediately preceding the breast cancer diagnosis. In multivariate-adjusted analyses, compared with never smokers, women who were current smokers had a 43% increased adjusted relative risk (RR) [95% confidence interval (95% CI): 1.24-1.65] of death from any cause. A strong linear gradient was observed with the number of cigarettes per day smoked, p-trend <0.0001; the RR (95% CI) for 1-14, 15-24 and 25 or more cigarettes per day was 1.27 (1.01-1.61), 1.30 (1.08-1.57) and 1.79 (1.47-2.19). In contrast, there was no association with current smoking and breast cancer death; the RR (95% CI) was 1.00 (0.83-1.19). Current and past smokers were more likely than never smokers to die from primary lung cancer, chronic obstructive pulmonary disease and other lung diseases. We conclude that a history of smoking increased mortality following diagnosis with breast cancer, but did not increase mortality from breast cancer.

Original languageEnglish (US)
Pages (from-to)2672-2677
Number of pages6
JournalInternational Journal of Cancer
Volume120
Issue number12
DOIs
StatePublished - Jun 15 2007
Externally publishedYes

Fingerprint

Smoking
Breast Neoplasms
Survival
Confidence Intervals
Tobacco Products
Cause of Death
Mortality
Women's Health
Chronic Obstructive Pulmonary Disease
Lung Diseases
Observational Studies
Lung Neoplasms
Multivariate Analysis
Nurses
Prospective Studies

Keywords

  • Breast neoplasms
  • Cohort studies
  • Smoking
  • Survival
  • Women

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Holmes, M. D., Murin, S., Chen, W. Y., Kroenke, C. H., Spiegelman, D., & Colditz, G. A. (2007). Smoking and survival after breast cancer diagnosis. International Journal of Cancer, 120(12), 2672-2677. https://doi.org/10.1002/ijc.22575

Smoking and survival after breast cancer diagnosis. / Holmes, Michelle D.; Murin, Susan; Chen, Wendy Y.; Kroenke, Candyce H.; Spiegelman, Donna; Colditz, Graham A.

In: International Journal of Cancer, Vol. 120, No. 12, 15.06.2007, p. 2672-2677.

Research output: Contribution to journalArticle

Holmes, MD, Murin, S, Chen, WY, Kroenke, CH, Spiegelman, D & Colditz, GA 2007, 'Smoking and survival after breast cancer diagnosis', International Journal of Cancer, vol. 120, no. 12, pp. 2672-2677. https://doi.org/10.1002/ijc.22575
Holmes MD, Murin S, Chen WY, Kroenke CH, Spiegelman D, Colditz GA. Smoking and survival after breast cancer diagnosis. International Journal of Cancer. 2007 Jun 15;120(12):2672-2677. https://doi.org/10.1002/ijc.22575
Holmes, Michelle D. ; Murin, Susan ; Chen, Wendy Y. ; Kroenke, Candyce H. ; Spiegelman, Donna ; Colditz, Graham A. / Smoking and survival after breast cancer diagnosis. In: International Journal of Cancer. 2007 ; Vol. 120, No. 12. pp. 2672-2677.
@article{52ca9dfe31f449d19cf397e2654d06ed,
title = "Smoking and survival after breast cancer diagnosis",
abstract = "We examined whether a history of smoking is associated with an increased risk of death from any cause or from breast cancer, among women diagnosed with breast cancer. This was a prospective observational study among 5,056 women from the Nurses' Health Study with Stages I-III invasive breast cancer diagnosed between 1978 and 2002 and for whom we had information on smoking, and who were followed until January 2002 or death, whichever came first. Subjects were classified as current, former or never smokers based upon smoking status at the biennial questionnaire immediately preceding the breast cancer diagnosis. In multivariate-adjusted analyses, compared with never smokers, women who were current smokers had a 43{\%} increased adjusted relative risk (RR) [95{\%} confidence interval (95{\%} CI): 1.24-1.65] of death from any cause. A strong linear gradient was observed with the number of cigarettes per day smoked, p-trend <0.0001; the RR (95{\%} CI) for 1-14, 15-24 and 25 or more cigarettes per day was 1.27 (1.01-1.61), 1.30 (1.08-1.57) and 1.79 (1.47-2.19). In contrast, there was no association with current smoking and breast cancer death; the RR (95{\%} CI) was 1.00 (0.83-1.19). Current and past smokers were more likely than never smokers to die from primary lung cancer, chronic obstructive pulmonary disease and other lung diseases. We conclude that a history of smoking increased mortality following diagnosis with breast cancer, but did not increase mortality from breast cancer.",
keywords = "Breast neoplasms, Cohort studies, Smoking, Survival, Women",
author = "Holmes, {Michelle D.} and Susan Murin and Chen, {Wendy Y.} and Kroenke, {Candyce H.} and Donna Spiegelman and Colditz, {Graham A.}",
year = "2007",
month = "6",
day = "15",
doi = "10.1002/ijc.22575",
language = "English (US)",
volume = "120",
pages = "2672--2677",
journal = "International Journal of Cancer",
issn = "0020-7136",
publisher = "Wiley-Liss Inc.",
number = "12",

}

TY - JOUR

T1 - Smoking and survival after breast cancer diagnosis

AU - Holmes, Michelle D.

AU - Murin, Susan

AU - Chen, Wendy Y.

AU - Kroenke, Candyce H.

AU - Spiegelman, Donna

AU - Colditz, Graham A.

PY - 2007/6/15

Y1 - 2007/6/15

N2 - We examined whether a history of smoking is associated with an increased risk of death from any cause or from breast cancer, among women diagnosed with breast cancer. This was a prospective observational study among 5,056 women from the Nurses' Health Study with Stages I-III invasive breast cancer diagnosed between 1978 and 2002 and for whom we had information on smoking, and who were followed until January 2002 or death, whichever came first. Subjects were classified as current, former or never smokers based upon smoking status at the biennial questionnaire immediately preceding the breast cancer diagnosis. In multivariate-adjusted analyses, compared with never smokers, women who were current smokers had a 43% increased adjusted relative risk (RR) [95% confidence interval (95% CI): 1.24-1.65] of death from any cause. A strong linear gradient was observed with the number of cigarettes per day smoked, p-trend <0.0001; the RR (95% CI) for 1-14, 15-24 and 25 or more cigarettes per day was 1.27 (1.01-1.61), 1.30 (1.08-1.57) and 1.79 (1.47-2.19). In contrast, there was no association with current smoking and breast cancer death; the RR (95% CI) was 1.00 (0.83-1.19). Current and past smokers were more likely than never smokers to die from primary lung cancer, chronic obstructive pulmonary disease and other lung diseases. We conclude that a history of smoking increased mortality following diagnosis with breast cancer, but did not increase mortality from breast cancer.

AB - We examined whether a history of smoking is associated with an increased risk of death from any cause or from breast cancer, among women diagnosed with breast cancer. This was a prospective observational study among 5,056 women from the Nurses' Health Study with Stages I-III invasive breast cancer diagnosed between 1978 and 2002 and for whom we had information on smoking, and who were followed until January 2002 or death, whichever came first. Subjects were classified as current, former or never smokers based upon smoking status at the biennial questionnaire immediately preceding the breast cancer diagnosis. In multivariate-adjusted analyses, compared with never smokers, women who were current smokers had a 43% increased adjusted relative risk (RR) [95% confidence interval (95% CI): 1.24-1.65] of death from any cause. A strong linear gradient was observed with the number of cigarettes per day smoked, p-trend <0.0001; the RR (95% CI) for 1-14, 15-24 and 25 or more cigarettes per day was 1.27 (1.01-1.61), 1.30 (1.08-1.57) and 1.79 (1.47-2.19). In contrast, there was no association with current smoking and breast cancer death; the RR (95% CI) was 1.00 (0.83-1.19). Current and past smokers were more likely than never smokers to die from primary lung cancer, chronic obstructive pulmonary disease and other lung diseases. We conclude that a history of smoking increased mortality following diagnosis with breast cancer, but did not increase mortality from breast cancer.

KW - Breast neoplasms

KW - Cohort studies

KW - Smoking

KW - Survival

KW - Women

UR - http://www.scopus.com/inward/record.url?scp=34247466994&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34247466994&partnerID=8YFLogxK

U2 - 10.1002/ijc.22575

DO - 10.1002/ijc.22575

M3 - Article

VL - 120

SP - 2672

EP - 2677

JO - International Journal of Cancer

JF - International Journal of Cancer

SN - 0020-7136

IS - 12

ER -