Smoking and pathogenesis of psoriasis: A review of oxidative, inflammatory and genetic mechanisms

A. W. Armstrong, E. J. Armstrong, E. N. Fuller, M. E. Sockolov, S. V. Voyles

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

Recent studies suggest that cigarette smoking may trigger the development of psoriasis through oxidative, inflammatory and genetic mechanisms. Smoking initiates formation of free radicals that stimulate cell signalling pathways active in psoriasis including mitogen-activated protein kinase (MAPK), nuclear factor-κB (NF-κB) and Janus kinase/signal transducers and activators of transcription (JAK-STAT). Smoking damages the skin by increasing formation of reactive oxygen species and decreasing the gene expression of antioxidants. Nicotine also stimulates innate immune cells integral to the pathogenesis of psoriasis including dendritic cells, macrophages and keratinocytes. These cells release cytokines that activate T lymphocytes and perpetuate a cycle of chronic inflammation. Smoking also enhances expression of genes known to confer an increased risk of psoriasis, including HLA-Cw6, HLA-DQA1 0201 and CYP1A1. Improved understanding of the possible link between smoking and psoriasis pathogenesis may provide further insight into mechanisms underlying smoking, psoriasis and risk of subsequent cardiovascular disease.

Original languageEnglish (US)
Pages (from-to)1162-1168
Number of pages7
JournalBritish Journal of Dermatology
Volume165
Issue number6
DOIs
StatePublished - Dec 2011

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Psoriasis
Smoking
Janus Kinases
Gene Expression
Cytochrome P-450 CYP1A1
Mitogen-Activated Protein Kinases
Transducers
Nicotine
Keratinocytes
Dendritic Cells
Free Radicals
Reactive Oxygen Species
Cardiovascular Diseases
Antioxidants
Macrophages
Cytokines
Inflammation
T-Lymphocytes
Skin

ASJC Scopus subject areas

  • Dermatology

Cite this

Smoking and pathogenesis of psoriasis : A review of oxidative, inflammatory and genetic mechanisms. / Armstrong, A. W.; Armstrong, E. J.; Fuller, E. N.; Sockolov, M. E.; Voyles, S. V.

In: British Journal of Dermatology, Vol. 165, No. 6, 12.2011, p. 1162-1168.

Research output: Contribution to journalArticle

Armstrong, A. W. ; Armstrong, E. J. ; Fuller, E. N. ; Sockolov, M. E. ; Voyles, S. V. / Smoking and pathogenesis of psoriasis : A review of oxidative, inflammatory and genetic mechanisms. In: British Journal of Dermatology. 2011 ; Vol. 165, No. 6. pp. 1162-1168.
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