Smoking and alcohol consumption in relation to risk of triple-negative breast cancer in a cohort of postmenopausal women

Geoffrey C. Kabat, Mimi Kim, Amanda I. Phipps, Christopher I. Li, Catherine R. Messina, Jean Wactawski-Wende, Lewis Kuller, Michael S. Simon, Shagufta Yasmeen, Sylvia Wassertheil-Smoller, Thomas E. Rohan

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Purpose: Little is known about the risk factors for triple-negative breast cancer (TNBC), which has a worse prognosis compared to hormone receptor-positive breast cancer. We examined the association of smoking and alcohol intake with TNBC and estrogen receptor-positive (ER+) breast cancer. Methods: Among 148,030 women enrolled in the Women's Health Initiative, 300 TNBC cases and 2,479 ER+ cases were identified over a median of 8.0 years of follow-up. Cox proportional hazards models were used to estimate hazard ratios (HR) and 95% confidence intervals (95% CI). Results: Cigarette smoking was not associated with TNBC, whereas drinkers had reduced risk compared to never drinkers. In contrast, both exposures showed slight positive associations with ER+ breast cancer: for women with ≥40 pack-years of smoking, the HR was 1.24, 95% CI 1.06-1.44; for women consuming ≥7 servings of alcohol per week, the HR was 1.26, 95% CI 1.06-1.50. Intakes of wine and hard liquor were also significantly positively associated with ER+ breast cancer. Conclusions: These findings from a large cohort of postmenopausal women suggest that smoking and alcohol consumption are not associated with increased risk of TNBC, but may be modestly associated with increased risk of ER+ breast cancer.

Original languageEnglish (US)
Pages (from-to)775-783
Number of pages9
JournalCancer Causes and Control
Volume22
Issue number5
DOIs
StatePublished - May 2011

Fingerprint

Triple Negative Breast Neoplasms
Alcohol Drinking
Smoking
Breast Neoplasms
Confidence Intervals
Alcohols
Women's Health
Wine
Proportional Hazards Models
Estrogen Receptors
Hormones

Keywords

  • Alcohol consumption
  • Breast neoplasms
  • Cigarette smoking
  • Estrogen receptor-positive
  • Postmenopausal women
  • Triple-negative

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Kabat, G. C., Kim, M., Phipps, A. I., Li, C. I., Messina, C. R., Wactawski-Wende, J., ... Rohan, T. E. (2011). Smoking and alcohol consumption in relation to risk of triple-negative breast cancer in a cohort of postmenopausal women. Cancer Causes and Control, 22(5), 775-783. https://doi.org/10.1007/s10552-011-9750-7

Smoking and alcohol consumption in relation to risk of triple-negative breast cancer in a cohort of postmenopausal women. / Kabat, Geoffrey C.; Kim, Mimi; Phipps, Amanda I.; Li, Christopher I.; Messina, Catherine R.; Wactawski-Wende, Jean; Kuller, Lewis; Simon, Michael S.; Yasmeen, Shagufta; Wassertheil-Smoller, Sylvia; Rohan, Thomas E.

In: Cancer Causes and Control, Vol. 22, No. 5, 05.2011, p. 775-783.

Research output: Contribution to journalArticle

Kabat, GC, Kim, M, Phipps, AI, Li, CI, Messina, CR, Wactawski-Wende, J, Kuller, L, Simon, MS, Yasmeen, S, Wassertheil-Smoller, S & Rohan, TE 2011, 'Smoking and alcohol consumption in relation to risk of triple-negative breast cancer in a cohort of postmenopausal women', Cancer Causes and Control, vol. 22, no. 5, pp. 775-783. https://doi.org/10.1007/s10552-011-9750-7
Kabat, Geoffrey C. ; Kim, Mimi ; Phipps, Amanda I. ; Li, Christopher I. ; Messina, Catherine R. ; Wactawski-Wende, Jean ; Kuller, Lewis ; Simon, Michael S. ; Yasmeen, Shagufta ; Wassertheil-Smoller, Sylvia ; Rohan, Thomas E. / Smoking and alcohol consumption in relation to risk of triple-negative breast cancer in a cohort of postmenopausal women. In: Cancer Causes and Control. 2011 ; Vol. 22, No. 5. pp. 775-783.
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