Small leucine-rich proteoglycans (SLRPs): Characteristics and function in the intervertebral disc

Lili Chen, Jingwen Liao, Eric Otto Klineberg, Victor Y L Leung, Shishu Huang

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The intervertebral disc (IVD) is responsible for normal spinal motion and load distribution. However, degeneration may occur due to age- and non-age-related processes and is primarily characterized by a reduction in the number of chondrocyte-like cells and abnormal extracellular matrix (ECM) structure in the nucleus pulposus. Although IVD progenitor cells have been identified, the local microenvironment components regulating the behaviour of these progenitor cell populations remain unknown. Small leucine-rich proteoglycans (SLRPs) are bioactive components of the ECM associated with fibrillogenesis, cellular growth and apoptosis and tissue remodelling. SLRPs support the survival of IVD progenitor cells under hypoxic conditions via the activation of specific hypoxia-inducible factors. Additionally, SLRPs deficiency (biglycan) in knockout mice is sufficient to accelerate the IVD degenerative process. These data suggest that SLRPs play an important role in the homeostasis of IVD. Given their specific properties and physiological functions, we propose a role of SLRPs in IVD degeneration and potential application in its regeneration.

Original languageEnglish (US)
JournalJournal of Tissue Engineering and Regenerative Medicine
DOIs
StateAccepted/In press - 2015

Fingerprint

Intervertebral Disc
Proteoglycans
Leucine
Intervertebral Disc Degeneration
Stem Cells
Extracellular Matrix
Biglycan
Cell death
Chondrocytes
Knockout Mice
Regeneration
Homeostasis
Chemical activation
Cells
Small Leucine-Rich Proteoglycans
Tissue
Apoptosis
Growth
Population

Keywords

  • Homeostasis
  • Hypoxia
  • Intervertebral disc
  • Knockout mice
  • Nucleus pulposus
  • Progenitor cell
  • Regeneration
  • SLRPs

ASJC Scopus subject areas

  • Biomedical Engineering
  • Medicine (miscellaneous)
  • Biomaterials

Cite this

Small leucine-rich proteoglycans (SLRPs) : Characteristics and function in the intervertebral disc. / Chen, Lili; Liao, Jingwen; Klineberg, Eric Otto; Leung, Victor Y L; Huang, Shishu.

In: Journal of Tissue Engineering and Regenerative Medicine, 2015.

Research output: Contribution to journalArticle

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