Small intestinal submucosa for patch grafting after plaque incision in the treatment of Peyronie's disease

Eugene W. Lee, Alan W Shindel, Steven B. Brandes

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Objective: Report the results using porcine small intestinal submucosa (SIS) as a graft material in the surgical management of Peyronie's disease (PD). Materials and Methods: We performed a retrospective chart review of men with PD who underwent surgical correction of the curvature by plaque "H" incision and patch grafting with 4-ply SIS (Cook, Bloomington, IN) by a single surgeon at our institution. Degree and direction of curvature, sexual function, and co-morbidities were assessed pre- and postoperatively. Results: Thirteen patients were identified. Mean age was 57 ± 8, range 42-70 years. Median follow-up was 14 months, range 3-89 months. At presentation, all reported penile curvature. Also reported were difficulty with vaginal penetration (determined by question number 2 of the sexual encounter profile questionnaire - SEP2), palpable plaque, hourglass deformity, difficulty with firmness, and difficulty with sustaining erection (determined by SEP3) in77%, 69%, 77%, 62%, and 46% of patients, respectively. Mean and median degrees of curvature of the primary deformity were 71 and 67.5 degrees, respectively. Three patients had secondary curves of less than 30 degrees in a different direction. Mean and median plaque size were 3.5 and 2.7 cm2, respectively. Seven patients had one graft and six patients had two grafts placed with a mean size of 15 ± 0 cm2. Conclusions: For the patient with PD, SIS grafting can achieve a functionally straight erection with durable results yet with relatively high rates of erectile dysfunction. SIS is a viable graft material for use in the surgical treatment of PD.

Original languageEnglish (US)
Pages (from-to)191-196
Number of pages6
JournalInternational Braz J Urol
Volume34
Issue number2
StatePublished - Mar 2008
Externally publishedYes

Fingerprint

Penile Induration
Transplants
Therapeutics
Erectile Dysfunction
Swine
Morbidity

Keywords

  • Graft
  • Penis
  • Peyronie's disease
  • Small intestinal submucosa
  • Surgery

ASJC Scopus subject areas

  • Nephrology

Cite this

Small intestinal submucosa for patch grafting after plaque incision in the treatment of Peyronie's disease. / Lee, Eugene W.; Shindel, Alan W; Brandes, Steven B.

In: International Braz J Urol, Vol. 34, No. 2, 03.2008, p. 191-196.

Research output: Contribution to journalArticle

@article{cdce4b4ef3884b1d9d4f43e47a7e1a5f,
title = "Small intestinal submucosa for patch grafting after plaque incision in the treatment of Peyronie's disease",
abstract = "Objective: Report the results using porcine small intestinal submucosa (SIS) as a graft material in the surgical management of Peyronie's disease (PD). Materials and Methods: We performed a retrospective chart review of men with PD who underwent surgical correction of the curvature by plaque {"}H{"} incision and patch grafting with 4-ply SIS (Cook, Bloomington, IN) by a single surgeon at our institution. Degree and direction of curvature, sexual function, and co-morbidities were assessed pre- and postoperatively. Results: Thirteen patients were identified. Mean age was 57 ± 8, range 42-70 years. Median follow-up was 14 months, range 3-89 months. At presentation, all reported penile curvature. Also reported were difficulty with vaginal penetration (determined by question number 2 of the sexual encounter profile questionnaire - SEP2), palpable plaque, hourglass deformity, difficulty with firmness, and difficulty with sustaining erection (determined by SEP3) in77{\%}, 69{\%}, 77{\%}, 62{\%}, and 46{\%} of patients, respectively. Mean and median degrees of curvature of the primary deformity were 71 and 67.5 degrees, respectively. Three patients had secondary curves of less than 30 degrees in a different direction. Mean and median plaque size were 3.5 and 2.7 cm2, respectively. Seven patients had one graft and six patients had two grafts placed with a mean size of 15 ± 0 cm2. Conclusions: For the patient with PD, SIS grafting can achieve a functionally straight erection with durable results yet with relatively high rates of erectile dysfunction. SIS is a viable graft material for use in the surgical treatment of PD.",
keywords = "Graft, Penis, Peyronie's disease, Small intestinal submucosa, Surgery",
author = "Lee, {Eugene W.} and Shindel, {Alan W} and Brandes, {Steven B.}",
year = "2008",
month = "3",
language = "English (US)",
volume = "34",
pages = "191--196",
journal = "International braz j urol : official journal of the Brazilian Society of Urology",
issn = "1677-5538",
publisher = "Brazilian Society of Urology",
number = "2",

}

TY - JOUR

T1 - Small intestinal submucosa for patch grafting after plaque incision in the treatment of Peyronie's disease

AU - Lee, Eugene W.

AU - Shindel, Alan W

AU - Brandes, Steven B.

PY - 2008/3

Y1 - 2008/3

N2 - Objective: Report the results using porcine small intestinal submucosa (SIS) as a graft material in the surgical management of Peyronie's disease (PD). Materials and Methods: We performed a retrospective chart review of men with PD who underwent surgical correction of the curvature by plaque "H" incision and patch grafting with 4-ply SIS (Cook, Bloomington, IN) by a single surgeon at our institution. Degree and direction of curvature, sexual function, and co-morbidities were assessed pre- and postoperatively. Results: Thirteen patients were identified. Mean age was 57 ± 8, range 42-70 years. Median follow-up was 14 months, range 3-89 months. At presentation, all reported penile curvature. Also reported were difficulty with vaginal penetration (determined by question number 2 of the sexual encounter profile questionnaire - SEP2), palpable plaque, hourglass deformity, difficulty with firmness, and difficulty with sustaining erection (determined by SEP3) in77%, 69%, 77%, 62%, and 46% of patients, respectively. Mean and median degrees of curvature of the primary deformity were 71 and 67.5 degrees, respectively. Three patients had secondary curves of less than 30 degrees in a different direction. Mean and median plaque size were 3.5 and 2.7 cm2, respectively. Seven patients had one graft and six patients had two grafts placed with a mean size of 15 ± 0 cm2. Conclusions: For the patient with PD, SIS grafting can achieve a functionally straight erection with durable results yet with relatively high rates of erectile dysfunction. SIS is a viable graft material for use in the surgical treatment of PD.

AB - Objective: Report the results using porcine small intestinal submucosa (SIS) as a graft material in the surgical management of Peyronie's disease (PD). Materials and Methods: We performed a retrospective chart review of men with PD who underwent surgical correction of the curvature by plaque "H" incision and patch grafting with 4-ply SIS (Cook, Bloomington, IN) by a single surgeon at our institution. Degree and direction of curvature, sexual function, and co-morbidities were assessed pre- and postoperatively. Results: Thirteen patients were identified. Mean age was 57 ± 8, range 42-70 years. Median follow-up was 14 months, range 3-89 months. At presentation, all reported penile curvature. Also reported were difficulty with vaginal penetration (determined by question number 2 of the sexual encounter profile questionnaire - SEP2), palpable plaque, hourglass deformity, difficulty with firmness, and difficulty with sustaining erection (determined by SEP3) in77%, 69%, 77%, 62%, and 46% of patients, respectively. Mean and median degrees of curvature of the primary deformity were 71 and 67.5 degrees, respectively. Three patients had secondary curves of less than 30 degrees in a different direction. Mean and median plaque size were 3.5 and 2.7 cm2, respectively. Seven patients had one graft and six patients had two grafts placed with a mean size of 15 ± 0 cm2. Conclusions: For the patient with PD, SIS grafting can achieve a functionally straight erection with durable results yet with relatively high rates of erectile dysfunction. SIS is a viable graft material for use in the surgical treatment of PD.

KW - Graft

KW - Penis

KW - Peyronie's disease

KW - Small intestinal submucosa

KW - Surgery

UR - http://www.scopus.com/inward/record.url?scp=44449154709&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=44449154709&partnerID=8YFLogxK

M3 - Article

C2 - 18462517

AN - SCOPUS:44449154709

VL - 34

SP - 191

EP - 196

JO - International braz j urol : official journal of the Brazilian Society of Urology

JF - International braz j urol : official journal of the Brazilian Society of Urology

SN - 1677-5538

IS - 2

ER -