Small intestinal enteropathy with epithelial IgG and complement deposition in children with regressive autism

F. Torrente, Paul Ashwood, R. Day, N. Machado, R. I. Furlano, A. Anthony, S. E. Davies, A. J. Wakefield, M. A. Thomson, J. A. Walker-Smith, S. H. Murch

Research output: Contribution to journalArticle

139 Citations (Scopus)

Abstract

We have reported lymphocytic colitis in children with regressive autism, with epithelial damage prominent. We now compare duodenal biopsies in 25 children with regressive autism to 11 with coeliac disease, five with cerebral palsy and mental retardation and 18 histologically normal controls. Immunohistochemistry was performed for lymphocyte and epithelial lineage and functional markers. We determined the density of intraepithelial and lamina propria lymphocyte populations, and studied mucosal immunoglobulin and complement C1q localisation. Standard histopathology showed increased enterocyte and Paneth cell numbers in the autistic children. Immunohistochemistry demonstrated increased lymphocyte infiltration in both epithelium and lamina propria with upregulated crypt cell proliferation, compared to normal and cerebral palsy controls. Intraepithelial lymphocytes and lamina propria plasma cells were lower than in coeliac disease, but lamina propria T cell populations were higher and crypt proliferation similar. Most strikingly, IgG deposition was seen on the basolateral epithelial surface in 23/25 autistic children, co-localising with complement C1q. This was not seen in the other conditions. These findings demonstrate a novel form of enteropathy in autistic children, in which increases in mucosal lymphocyte density and crypt cell proliferation occur with epithelial IgG deposition. The features are suggestive of an autoimmune lesion.

Original languageEnglish (US)
Pages (from-to)375-382
Number of pages8
JournalMolecular Psychiatry
Volume7
Issue number4
DOIs
StatePublished - Jan 1 2002
Externally publishedYes

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Autistic Disorder
Immunoglobulin G
Lymphocytes
Mucous Membrane
Complement C1q
Celiac Disease
Cerebral Palsy
Lymphocytic Colitis
Immunohistochemistry
Cell Proliferation
Paneth Cells
Enterocytes
Plasma Cells
Intellectual Disability
Population
Immunoglobulins
Epithelium
Cell Count
T-Lymphocytes
Biopsy

Keywords

  • Autism
  • Autoimmunity
  • Complement
  • Immunoglobulins
  • Inflammation
  • Lymphocytes
  • Small intestine

ASJC Scopus subject areas

  • Molecular Biology
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

Cite this

Small intestinal enteropathy with epithelial IgG and complement deposition in children with regressive autism. / Torrente, F.; Ashwood, Paul; Day, R.; Machado, N.; Furlano, R. I.; Anthony, A.; Davies, S. E.; Wakefield, A. J.; Thomson, M. A.; Walker-Smith, J. A.; Murch, S. H.

In: Molecular Psychiatry, Vol. 7, No. 4, 01.01.2002, p. 375-382.

Research output: Contribution to journalArticle

Torrente, F, Ashwood, P, Day, R, Machado, N, Furlano, RI, Anthony, A, Davies, SE, Wakefield, AJ, Thomson, MA, Walker-Smith, JA & Murch, SH 2002, 'Small intestinal enteropathy with epithelial IgG and complement deposition in children with regressive autism', Molecular Psychiatry, vol. 7, no. 4, pp. 375-382. https://doi.org/10.1038/sj.mp.4001077
Torrente, F. ; Ashwood, Paul ; Day, R. ; Machado, N. ; Furlano, R. I. ; Anthony, A. ; Davies, S. E. ; Wakefield, A. J. ; Thomson, M. A. ; Walker-Smith, J. A. ; Murch, S. H. / Small intestinal enteropathy with epithelial IgG and complement deposition in children with regressive autism. In: Molecular Psychiatry. 2002 ; Vol. 7, No. 4. pp. 375-382.
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