Small cell carcinoma of the urinary bladder: A clinicopathologic analysis of 64 patients

Liang Cheng, Chong-Xian Pan, Ximing J. Yang, Antonio Lopez-Beltran, Gregory T. MacLennan, Haiqun Lin, Timothy M. Kuzel, Veronica Papavero, Maria Tretiakova, Kelly Nigro, Michael O. Koch, John N. Eble

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Abstract

BACKGROUND. Small cell carcinoma of the urinary bladder is an uncommon tumor that has been described in case reports or small series. Herein, the authors report a series of 64 patients with small cell carcinoma of the urinary bladder. METHODS. Histologic slides and medical records from 64 patients with small cell carcinoma of the urinary bladder were reviewed for morphologic, demographic, and clinical data. All patients fulfilled the criteria established for small cell carcinoma according to the World Health Organization classification system. The 2002 tumor, lymph node, and metastasis (TNM) system was used for pathologic staging. The correlations of various clinicopathologic characteristics with survival were analyzed. RESULTS. Patients ranged in age from 36 years to 85 years (mean age, 66 years). The male-to-female ratio was 3.3:1.0. Among patients with clinical information available, 65% had a history of cigarette smoking, and 88% presented with hematuria. All but one patient had muscle-invasive disease at presentation. Thirty-eight patients (59%) underwent cystectomy. Sixty-six percent of patients had lymph node metastasis at the time of cystectomy. Twenty patients (32%) had pure small cell carcinoma, and 44 patients (68%) had small cell carcinoma with other histologic types (35 patients had urothelial carcinoma, 4 patients had adenocarcinoma, 2 patients had sarcomatoid urothelial carcinoma, and 3 patients had both adenocarcinoma and urothelial carcinoma). With a mean follow-up of 21 months, 68% of patients died of bladder carcinoma. None of the clinicopathologic parameters studied (age, gender, presenting symptoms, smoking history, the presence of a nonsmall cell carcinoma component, chemotherapy, or radiation therapy) were associated with survival. No significant survival difference was found between patients who did and did not undergo cystectomy (P = 0.65). Patients who had organ-confined disease had marginally better survival compared with patients who had nonorgan-confined disease (P = 0.06). The overall, 1-year, 18-month, 3-year, and 5-year disease-specific survival rates were 56%, 41%, 23%, and 16%, respectively. CONCLUSIONS. The prognosis for patients with small cell carcinoma of the urinary bladder remains poor, even though the overall survival for patients with bladder carcinoma has improved significantly over the last decade.

Original languageEnglish (US)
Pages (from-to)957-962
Number of pages6
JournalCancer
Volume101
Issue number5
DOIs
StatePublished - Sep 1 2004
Externally publishedYes

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Small Cell Carcinoma
Urinary Bladder
Carcinoma
Cystectomy
Survival
Adenocarcinoma
Lymph Nodes
Smoking
Neoplasm Metastasis

Keywords

  • Cystectomy
  • Neoplasm
  • Prognosis
  • Small cell carcinoma
  • Staging
  • Treatment
  • Urinary bladder

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Cheng, L., Pan, C-X., Yang, X. J., Lopez-Beltran, A., MacLennan, G. T., Lin, H., ... Eble, J. N. (2004). Small cell carcinoma of the urinary bladder: A clinicopathologic analysis of 64 patients. Cancer, 101(5), 957-962. https://doi.org/10.1002/cncr.20456

Small cell carcinoma of the urinary bladder : A clinicopathologic analysis of 64 patients. / Cheng, Liang; Pan, Chong-Xian; Yang, Ximing J.; Lopez-Beltran, Antonio; MacLennan, Gregory T.; Lin, Haiqun; Kuzel, Timothy M.; Papavero, Veronica; Tretiakova, Maria; Nigro, Kelly; Koch, Michael O.; Eble, John N.

In: Cancer, Vol. 101, No. 5, 01.09.2004, p. 957-962.

Research output: Contribution to journalArticle

Cheng, L, Pan, C-X, Yang, XJ, Lopez-Beltran, A, MacLennan, GT, Lin, H, Kuzel, TM, Papavero, V, Tretiakova, M, Nigro, K, Koch, MO & Eble, JN 2004, 'Small cell carcinoma of the urinary bladder: A clinicopathologic analysis of 64 patients', Cancer, vol. 101, no. 5, pp. 957-962. https://doi.org/10.1002/cncr.20456
Cheng L, Pan C-X, Yang XJ, Lopez-Beltran A, MacLennan GT, Lin H et al. Small cell carcinoma of the urinary bladder: A clinicopathologic analysis of 64 patients. Cancer. 2004 Sep 1;101(5):957-962. https://doi.org/10.1002/cncr.20456
Cheng, Liang ; Pan, Chong-Xian ; Yang, Ximing J. ; Lopez-Beltran, Antonio ; MacLennan, Gregory T. ; Lin, Haiqun ; Kuzel, Timothy M. ; Papavero, Veronica ; Tretiakova, Maria ; Nigro, Kelly ; Koch, Michael O. ; Eble, John N. / Small cell carcinoma of the urinary bladder : A clinicopathologic analysis of 64 patients. In: Cancer. 2004 ; Vol. 101, No. 5. pp. 957-962.
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abstract = "BACKGROUND. Small cell carcinoma of the urinary bladder is an uncommon tumor that has been described in case reports or small series. Herein, the authors report a series of 64 patients with small cell carcinoma of the urinary bladder. METHODS. Histologic slides and medical records from 64 patients with small cell carcinoma of the urinary bladder were reviewed for morphologic, demographic, and clinical data. All patients fulfilled the criteria established for small cell carcinoma according to the World Health Organization classification system. The 2002 tumor, lymph node, and metastasis (TNM) system was used for pathologic staging. The correlations of various clinicopathologic characteristics with survival were analyzed. RESULTS. Patients ranged in age from 36 years to 85 years (mean age, 66 years). The male-to-female ratio was 3.3:1.0. Among patients with clinical information available, 65{\%} had a history of cigarette smoking, and 88{\%} presented with hematuria. All but one patient had muscle-invasive disease at presentation. Thirty-eight patients (59{\%}) underwent cystectomy. Sixty-six percent of patients had lymph node metastasis at the time of cystectomy. Twenty patients (32{\%}) had pure small cell carcinoma, and 44 patients (68{\%}) had small cell carcinoma with other histologic types (35 patients had urothelial carcinoma, 4 patients had adenocarcinoma, 2 patients had sarcomatoid urothelial carcinoma, and 3 patients had both adenocarcinoma and urothelial carcinoma). With a mean follow-up of 21 months, 68{\%} of patients died of bladder carcinoma. None of the clinicopathologic parameters studied (age, gender, presenting symptoms, smoking history, the presence of a nonsmall cell carcinoma component, chemotherapy, or radiation therapy) were associated with survival. No significant survival difference was found between patients who did and did not undergo cystectomy (P = 0.65). Patients who had organ-confined disease had marginally better survival compared with patients who had nonorgan-confined disease (P = 0.06). The overall, 1-year, 18-month, 3-year, and 5-year disease-specific survival rates were 56{\%}, 41{\%}, 23{\%}, and 16{\%}, respectively. CONCLUSIONS. The prognosis for patients with small cell carcinoma of the urinary bladder remains poor, even though the overall survival for patients with bladder carcinoma has improved significantly over the last decade.",
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AU - Lopez-Beltran, Antonio

AU - MacLennan, Gregory T.

AU - Lin, Haiqun

AU - Kuzel, Timothy M.

AU - Papavero, Veronica

AU - Tretiakova, Maria

AU - Nigro, Kelly

AU - Koch, Michael O.

AU - Eble, John N.

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N2 - BACKGROUND. Small cell carcinoma of the urinary bladder is an uncommon tumor that has been described in case reports or small series. Herein, the authors report a series of 64 patients with small cell carcinoma of the urinary bladder. METHODS. Histologic slides and medical records from 64 patients with small cell carcinoma of the urinary bladder were reviewed for morphologic, demographic, and clinical data. All patients fulfilled the criteria established for small cell carcinoma according to the World Health Organization classification system. The 2002 tumor, lymph node, and metastasis (TNM) system was used for pathologic staging. The correlations of various clinicopathologic characteristics with survival were analyzed. RESULTS. Patients ranged in age from 36 years to 85 years (mean age, 66 years). The male-to-female ratio was 3.3:1.0. Among patients with clinical information available, 65% had a history of cigarette smoking, and 88% presented with hematuria. All but one patient had muscle-invasive disease at presentation. Thirty-eight patients (59%) underwent cystectomy. Sixty-six percent of patients had lymph node metastasis at the time of cystectomy. Twenty patients (32%) had pure small cell carcinoma, and 44 patients (68%) had small cell carcinoma with other histologic types (35 patients had urothelial carcinoma, 4 patients had adenocarcinoma, 2 patients had sarcomatoid urothelial carcinoma, and 3 patients had both adenocarcinoma and urothelial carcinoma). With a mean follow-up of 21 months, 68% of patients died of bladder carcinoma. None of the clinicopathologic parameters studied (age, gender, presenting symptoms, smoking history, the presence of a nonsmall cell carcinoma component, chemotherapy, or radiation therapy) were associated with survival. No significant survival difference was found between patients who did and did not undergo cystectomy (P = 0.65). Patients who had organ-confined disease had marginally better survival compared with patients who had nonorgan-confined disease (P = 0.06). The overall, 1-year, 18-month, 3-year, and 5-year disease-specific survival rates were 56%, 41%, 23%, and 16%, respectively. CONCLUSIONS. The prognosis for patients with small cell carcinoma of the urinary bladder remains poor, even though the overall survival for patients with bladder carcinoma has improved significantly over the last decade.

AB - BACKGROUND. Small cell carcinoma of the urinary bladder is an uncommon tumor that has been described in case reports or small series. Herein, the authors report a series of 64 patients with small cell carcinoma of the urinary bladder. METHODS. Histologic slides and medical records from 64 patients with small cell carcinoma of the urinary bladder were reviewed for morphologic, demographic, and clinical data. All patients fulfilled the criteria established for small cell carcinoma according to the World Health Organization classification system. The 2002 tumor, lymph node, and metastasis (TNM) system was used for pathologic staging. The correlations of various clinicopathologic characteristics with survival were analyzed. RESULTS. Patients ranged in age from 36 years to 85 years (mean age, 66 years). The male-to-female ratio was 3.3:1.0. Among patients with clinical information available, 65% had a history of cigarette smoking, and 88% presented with hematuria. All but one patient had muscle-invasive disease at presentation. Thirty-eight patients (59%) underwent cystectomy. Sixty-six percent of patients had lymph node metastasis at the time of cystectomy. Twenty patients (32%) had pure small cell carcinoma, and 44 patients (68%) had small cell carcinoma with other histologic types (35 patients had urothelial carcinoma, 4 patients had adenocarcinoma, 2 patients had sarcomatoid urothelial carcinoma, and 3 patients had both adenocarcinoma and urothelial carcinoma). With a mean follow-up of 21 months, 68% of patients died of bladder carcinoma. None of the clinicopathologic parameters studied (age, gender, presenting symptoms, smoking history, the presence of a nonsmall cell carcinoma component, chemotherapy, or radiation therapy) were associated with survival. No significant survival difference was found between patients who did and did not undergo cystectomy (P = 0.65). Patients who had organ-confined disease had marginally better survival compared with patients who had nonorgan-confined disease (P = 0.06). The overall, 1-year, 18-month, 3-year, and 5-year disease-specific survival rates were 56%, 41%, 23%, and 16%, respectively. CONCLUSIONS. The prognosis for patients with small cell carcinoma of the urinary bladder remains poor, even though the overall survival for patients with bladder carcinoma has improved significantly over the last decade.

KW - Cystectomy

KW - Neoplasm

KW - Prognosis

KW - Small cell carcinoma

KW - Staging

KW - Treatment

KW - Urinary bladder

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