Slow depolarizing potentials in 'epileptic' neurons

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19 Scopus citations


Slow depolarizing potentials following penicillin-induced epileptiform bursting were recorded intracellularly from rat cortical neurons in vivo and guinea pig hippocampal neurons in vitro. In in vitro experiments, it was shown that blocking potassium conductance with tetraethylammonium resulted in epileptiform bursting and afterpotentials similar to those seen with penicillin application. It is hypothesized that an abnormality in potassium conductance, and a resulting increase in calcium influx, could be responsible for the long depolarization characteristic of some neurons in epileptic foci.

Original languageEnglish (US)
Pages (from-to)267-277
Number of pages11
Issue number3
StatePublished - 1979
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)


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