Sliding filaments and mitotic spindle organization

Haifeng Wang; Ingrid Brust-Mascher; Jonathan M. Scholey

doi:10.1038/ncb3019

Sliding filaments and mitotic spindle organization

Haifeng Wang, Ingrid Brust-Mascher, Jonathan M. Scholey

Molecular and Cellular Biology

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Mitosis depends upon the action of the mitotic spindle, a subcellular machine that uses microtubules (MTs) and motors to assemble itself and to coordinate chromosome segregation. Recent work illuminates how the motor-driven poleward sliding of MTs-nucleated at centrosomes, chromosomes and on pre-existing MTs-contributes to spindle assembly and length control.

Original language	English (US)
Pages (from-to)	737-739
Number of pages	3
Journal	Nature Cell Biology
Volume	16
Issue number	8
DOIs	https://doi.org/10.1038/ncb3019
State	Published - 2014

ASJC Scopus subject areas

Cell Biology
Medicine(all)

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title = "Sliding filaments and mitotic spindle organization",

abstract = "Mitosis depends upon the action of the mitotic spindle, a subcellular machine that uses microtubules (MTs) and motors to assemble itself and to coordinate chromosome segregation. Recent work illuminates how the motor-driven poleward sliding of MTs-nucleated at centrosomes, chromosomes and on pre-existing MTs-contributes to spindle assembly and length control.",

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AB - Mitosis depends upon the action of the mitotic spindle, a subcellular machine that uses microtubules (MTs) and motors to assemble itself and to coordinate chromosome segregation. Recent work illuminates how the motor-driven poleward sliding of MTs-nucleated at centrosomes, chromosomes and on pre-existing MTs-contributes to spindle assembly and length control.

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Sliding filaments and mitotic spindle organization

Abstract

ASJC Scopus subject areas

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