Slide Over: Advances in Slide-Free Optical Microscopy as Drivers of Diagnostic Pathology

Yehe Liu, Richard M. Levenson, Michael W. Jenkins

Research output: Contribution to journalReview articlepeer-review

Abstract

Conventional analysis using clinical histopathology is based on bright-field microscopy of thinly sliced tissue specimens. Although bright-field microscopy is a simple and robust method of examining microscope slides, the preparation of the slides needed is a lengthy and labor-intensive process. Slide-free histopathology, however, uses direct imaging of intact, minimally processed tissue samples using advanced optical-imaging systems, bypassing the extended workflow now required for the preparation of tissue sections. This article explains the technical basis of slide-free microscopy, reviews common slide-free optical microscopy techniques, and discusses the opportunities and challenges involved in clinical implementation.

Original languageEnglish (US)
Pages (from-to)180-194
Number of pages15
JournalAmerican Journal of Pathology
Volume192
Issue number2
DOIs
StatePublished - Feb 2022

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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