Sleepiness, fatigue, and risk of obstructive sleep apnea using the STOP-BANG questionnaire in multiple sclerosis: A pilot study

Robert A. Dias, Kimberly A Hardin, Heather Rose, Mark A. Agius, Michelle L Apperson, Steven D. Brass

Research output: Contribution to journalArticle

21 Scopus citations


Purpose: This study aims: (1) to identify patients with multiple sclerosis (MS) who are at high risk for obstructive sleep apnea (OSA) by utilizing the STOP-BANG questionnaire and (2) to evaluate the relationship between OSA risk as determined by the STOP-BANG questionnaire and self-reported sleepiness and fatigue using the Epworth Sleepiness Scale (ESS) and the Fatigue Severity Scale (FSS), respectively. Methods: A total of 120 consecutive patients presenting to the UC Davis Neurology MS Clinic were invited to participate in an anonymous survey. The exclusion criteria were: age <18 years, indefinite MS diagnosis, or incomplete survey. Results: There were 103 subjects included in our study: 42% of subjects (n = 43) met the criteria for high-risk OSA, 69% of subjects (n = 71) screened high for fatigue (FSS ≥ 4), but only 24 subjects (23%) screened high for excessive daytime sleepiness (ESS > 10). In males, 44% of the variation in ESS scores and 63% in FSS scores were explained by the STOP-BANG components. However, only 17% of the variation in ESS scores and 15% of the variation in FSS scores was explained by the STOP-BANG components in females. Conclusions: Over 40% of MS patients were identified as high risk for OSA based on the STOP-BANG questionnaire. The STOP-BANG questionnaire offers clinicians an efficient and objective tool for improving detection of OSA risk in MS patients.

Original languageEnglish (US)
Pages (from-to)1255-1265
Number of pages11
JournalSleep and Breathing
Issue number4
StatePublished - Dec 2012



  • Fatigue
  • Multiple sclerosis
  • Obstructive sleep apnea
  • Sleepiness

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Clinical Neurology
  • Medicine(all)

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